Mersin University, Faculty of Medicine, Department of Emergency Medicine, Turkey.
Mersin University, Faculty of Medicine, Department of Emergency Medicine, Turkey.
Am J Emerg Med. 2019 Mar;37(3):411-414. doi: 10.1016/j.ajem.2018.05.075. Epub 2018 May 30.
Mean platelet volume (MPV) is an inflammatory marker. Recent studies have shown that there is a negative correlation between platelet count (PC) and MPV and that the ratio of these two values may be more meaningful. The aim of our study was to investigate the diagnostic value of MPV and the MPV/PC ratio in acute appendicitis.
Patients who were admitted to the emergency department and underwent appendectomy for acute appendicitis between January 2013 and May 2016 were evaluated retrospectively. The patients were divided into three groups based on their histopathological findings: the control group (negative appendicectomy) and the uncomplicated and complicated appendicitis groups. Leukocyte count, CRP (C-reactive protein) levels, PC, MPV and the MPV/PC ratio were compared among the groups.
A total of 424 patients, including 231 men, were included in the study. The average age of all patients was 34.9 ± 13.2 years. There was no statistically significant difference between the uncomplicated appendicitis, complicated appendicitis and control groups in terms of MPV, PC and the MPV/PC ratio. Leukocyte count had a strong discriminatory property based on the area under curve (AUC) 0.73, (p < 0.001). CRP levels, MPV, PC and the MPV/PC ratio had weak discriminatory power with AUC values <0.65. Using receiver operating characteristic (ROC) analysis, the sensitivity and specificity of MPV were 83.79% and 23.21%, respectively, and 66.48% and 48.21%, respectively, for the MPV/PC ratio.
In our study, MPV and the MPV/PC ratio were not useful in the diagnosis of acute appendicitis.
平均血小板体积（MPV）是一种炎症标志物。最近的研究表明，血小板计数（PC）与 MPV 呈负相关，并且这两个值的比值可能更有意义。我们的研究目的是探讨 MPV 和 MPV/PC 比值在急性阑尾炎中的诊断价值。
回顾性评估 2013 年 1 月至 2016 年 5 月因急性阑尾炎在急诊科接受阑尾切除术的患者。根据组织病理学发现将患者分为三组：对照组（阴性阑尾切除术）和单纯性和复杂性阑尾炎组。比较各组之间的白细胞计数、CRP（C 反应蛋白）水平、PC、MPV 和 MPV/PC 比值。
本研究共纳入 424 例患者，其中 231 例为男性，平均年龄为 34.9±13.2 岁。在单纯性阑尾炎、复杂性阑尾炎和对照组之间，MPV、PC 和 MPV/PC 比值均无统计学差异。白细胞计数的曲线下面积（AUC）为 0.73，具有较强的判别能力（p<0.001）。CRP 水平、MPV、PC 和 MPV/PC 比值的 AUC 值均<0.65，具有较弱的判别能力。使用受试者工作特征（ROC）分析，MPV 的敏感性和特异性分别为 83.79%和 23.21%，MPV/PC 比值的敏感性和特异性分别为 66.48%和 48.21%。
在本研究中，MPV 和 MPV/PC 比值在急性阑尾炎的诊断中没有用处。
