Fedotov V P
Probl Endokrinol (Mosk). 1985 Sep-Oct;31(5):27-30.
The author presents the results obtained at the Laboratory of Hormone Biological Standardization, Institute of Experimental Endocrinology and Chemistry of Hormones, AMS USSR. The combination of adenohypophyseal cell cultivation with radioimmunoassay to determine hypophyseal hormones and the technique of labeled precursors provided an opportunity to definea group of regulators influencing the adenohypophysis directly, and to isolate it from biologically active factors, a hypophyseotropic effect of which is mediated by the hypothalamus. It has been shown that some secretogenes can play the role of the regulators of cell division in the adenohypophysis. The effects of the hormonal regulators on the proliferation and differentiation of hypophyseocytes are made both directly and indirectly. The diversity of regulatory effects on some hypophyseal functions is emphasized; it results in the recognition of heterogeneity of some endocrinopathies previously regarded as belonging to the same nosological entities.
作者介绍了在苏联医学科学院实验内分泌学与激素化学研究所激素生物标准化实验室所取得的结果。腺垂体细胞培养与放射免疫测定相结合以测定垂体激素，以及标记前体技术，为确定一组直接影响腺垂体的调节因子提供了机会，并将其与生物活性因子区分开来，后者的促垂体作用是由下丘脑介导的。已经表明，一些促分泌素可以在腺垂体中发挥细胞分裂调节因子的作用。激素调节因子对垂体细胞增殖和分化的影响既有直接的，也有间接的。强调了对某些垂体功能调节作用的多样性；这导致认识到一些以前被认为属于同一疾病实体的内分泌病的异质性。
