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血管性帕金森综合征的多巴胺转运体扫描结果与帕金森病相似。

Vascular parkinsonism showing dopamine transporter scan findings mimicking those of Parkinson's disease.

作者信息

Sakuramoto Hirotaka, Fujita Hiroaki, Ogaki Keitaro, Suzuki Keisuke

机构信息

Department of Neurology, Dokkyo Medical University, Japan.

出版信息

eNeurologicalSci. 2024 Sep 18;37:100528. doi: 10.1016/j.ensci.2024.100528. eCollection 2024 Dec.

DOI:10.1016/j.ensci.2024.100528
PMID:39346749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11437957/
Abstract

Dopamine transporter (DAT) scan is important in the diagnosis of Parkinson's disease (PD). We herein report a patient with vascular parkinsonism (VP) who showed dopamine transporter (DAT) scan findings which mimicked those typically seen in patients with Parkinson's disease (PD). DAT scan findings in patients with VP are characterized by a lower striatal asymmetry index than in patients with PD and decreased uptake in the area consistent with old cerebral infarction or hemorrhage. However, we should be aware that, as in our patient, VP patients with asymmetric basal ganglia lesions, may show increased striatal asymmetry index and asymmetric DAT scan findings.

摘要

多巴胺转运体(DAT)扫描在帕金森病(PD)的诊断中很重要。我们在此报告1例血管性帕金森综合征(VP)患者,其多巴胺转运体(DAT)扫描结果与帕金森病(PD)患者典型所见相似。VP患者的DAT扫描结果特点是纹状体不对称指数低于PD患者,且在与陈旧性脑梗死或出血相符的区域摄取减少。然而,我们应该意识到,正如我们的患者一样,有不对称基底节病变的VP患者可能会出现纹状体不对称指数增加和DAT扫描结果不对称的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8503/11437957/c45c118a5a24/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8503/11437957/c45c118a5a24/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8503/11437957/c45c118a5a24/gr1.jpg

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本文引用的文献

1
Clinical utility of DaTscan in patients with suspected Parkinsonian syndrome: a systematic review and meta-analysis.DaTscan在疑似帕金森综合征患者中的临床应用:一项系统评价和荟萃分析。
NPJ Parkinsons Dis. 2021 May 24;7(1):43. doi: 10.1038/s41531-021-00185-8.
2
The pattern of FP-CIT PET in pure white matter hyperintensities-related vascular parkinsonism.纯脑白质高信号相关血管性帕金森病中 FP-CIT PET 的模式。
Parkinsonism Relat Disord. 2021 Jan;82:1-6. doi: 10.1016/j.parkreldis.2020.11.002. Epub 2020 Nov 10.
3
Neuroimaging in Vascular Parkinsonism.
血管性帕金森病的神经影像学。
Curr Neurol Neurosci Rep. 2019 Nov 26;19(12):102. doi: 10.1007/s11910-019-1019-7.
4
Clinical features and 123I-FP-CIT SPECT imaging in vascular parkinsonism and Parkinson's disease.血管性帕金森病与帕金森病的临床特征及 123I-FP-CIT SPECT 成像。
J Neurol Neurosurg Psychiatry. 2013 Feb;84(2):122-9. doi: 10.1136/jnnp-2012-302618. Epub 2012 Aug 20.
5
[(123) I]FP-CIT-SPECT asymmetry index to differentiate Parkinson's disease from vascular parkinsonism.[(123) I]FP-CIT-SPECT 不对称指数可用于区分帕金森病与血管性帕金森综合征。
Acta Neurol Scand. 2012 Jul;126(1):12-6. doi: 10.1111/j.1600-0404.2011.01583.x. Epub 2011 Sep 14.
6
[123I]beta-CIT SPECT distinguishes vascular parkinsonism from Parkinson's disease.[123I]β-CIT单光子发射计算机断层扫描可区分血管性帕金森综合征与帕金森病。
Mov Disord. 2002 May;17(3):518-23. doi: 10.1002/mds.10092.