Bali Semiha Kevser, Martin Rebecca, Almeida Nuno M S, Saunders Catherine, Wilson Angela K
Department of Chemistry and MSU Center for PFAS Research, Michigan State University, East Lansing, Michigan 48864, United States.
ACS Omega. 2024 Sep 10;9(38):39554-39563. doi: 10.1021/acsomega.4c03578. eCollection 2024 Sep 24.
Per- and polyfluoroalkyl substances (PFAS) are a group of environmental pollutants that have been linked to a variety of health problems in humans, including the disruption of thyroid functions. Herein, for the first time, the impact of PFAS on thyroid hormone synthesis is shown. Mid- to long-chain PFAS impact thyroid hormone synthesis by changing the local hydrogen bond network as well as the required orientation of hormonogenic residues, stopping the production of thyroxine (T4). Furthermore, the toxic effects of sulfonic PFAS are more prominent than those of carboxylic PFAS, highlighting that the exposure to these specific compounds can pose greater problems for thyroid homeostasis.
全氟和多氟烷基物质（PFAS）是一类环境污染物，已被证明与人类的多种健康问题有关，包括甲状腺功能紊乱。在此，首次展示了PFAS对甲状腺激素合成的影响。中长链PFAS通过改变局部氢键网络以及激素生成残基的所需取向来影响甲状腺激素合成，从而阻止甲状腺素（T4）的产生。此外，磺酸型PFAS的毒性作用比羧酸型PFAS更为显著，这突出表明接触这些特定化合物会给甲状腺内环境稳定带来更大问题。
