镰状细胞病患者的非侵入性光学和实验室血液生物标志物具有相关性。
Non-invasive optical and laboratory hematologic biomarkers correlate in patients with sickle cell disease.
作者信息
Quang Timothy, Mostashari Golnar, Berning Elise, Gopalan Bindu Parachalil, Lizarralde-Iragorri Maria A, Lovins Dianna, Shet Arun S, Tromberg Bruce J
机构信息
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA.
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20814, USA.
出版信息
Biomed Opt Express. 2024 Jul 26;15(8):4829-4841. doi: 10.1364/BOE.527770. eCollection 2024 Aug 1.
The goal of this study is to identify non-invasive optical hemodynamic biomarkers that can index laboratory hematology measurements in sickle cell disease (SCD). We acquired frequency-domain NIRS (FD-NIRS) and diffuse correlation spectroscopy (DCS) data from the forearms and foreheads of 17 participants in a randomized, double-blind, placebo-controlled trial evaluating effects of isoquercetin (IQ) on thromboinflammation in SCD. We observed multiple, significant correlations between optical and hematology biomarkers including cerebral tissue oxygen saturation (StO) and hematocrit (HCT); oxyhemoglobin ([OHb]) recovery rate and intercellular adhesion molecule 1 (ICAM-1); and blood flow index (BFI) reperfusion rate and coagulation index (CI). The potential of these non-invasive optical biomarkers for assessing vascular pathophysiology for the management of SCD warrants further exploration.
本研究的目的是识别能够反映镰状细胞病（SCD）实验室血液学测量指标的非侵入性光学血流动力学生物标志物。在一项评估异槲皮苷（IQ）对SCD血栓炎症影响的随机、双盲、安慰剂对照试验中，我们采集了17名参与者前臂和前额的频域近红外光谱（FD-NIRS）和扩散相关光谱（DCS）数据。我们观察到光学和血液学生物标志物之间存在多种显著相关性，包括脑组织氧饱和度（StO）和血细胞比容（HCT）；氧合血红蛋白（[OHb]）恢复率和细胞间黏附分子1（ICAM-1）；以及血流指数（BFI）再灌注率和凝血指数（CI）。这些非侵入性光学生物标志物在评估SCD血管病理生理学以进行管理方面的潜力值得进一步探索。
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