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揭开入侵者的面纱：一例酷似胶质瘤的肺癌病例。

Unmasking the Intruder: A Case of Lung Carcinoma Mimicking As Glioma.

作者信息

Christopher Joana, Johnson Thanka, Kannan Anbukkarasi, Rengarajan Santhanam

机构信息

Pathology, Sree Balaji Medical College and Hospital, Chennai, IND.

Neurosurgery, Sree Balaji Medical College and Hospital, Chennai, IND.

出版信息

Cureus. 2024 Aug 28;16(8):e68035. doi: 10.7759/cureus.68035. eCollection 2024 Aug.

DOI:10.7759/cureus.68035
PMID:39347172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11432779/
Abstract

Lung carcinoma with metastases to the brain typically involves the cerebral hemispheres, occasionally the cerebellum and rarely the brainstem. This report presents the case of a 73-year-old male who complained of neurological symptoms of left-sided limb weakness and was initially diagnosed with a high-grade glioma. With further radiological investigations, our patient was found to have primary bronchogenic carcinoma with metastasis to the brain. He underwent craniotomy with decompression of the mass and is currently undergoing chemotherapy. This case calls for the collaborative effort needed to diagnose brain metastases and the importance of histopathology for confirmation of the same.

摘要

伴有脑转移的肺癌通常累及大脑半球，偶尔累及小脑，很少累及脑干。本报告介绍了一名73岁男性患者的病例，该患者主诉左侧肢体无力的神经症状，最初被诊断为高级别胶质瘤。经进一步影像学检查，发现我们的患者患有原发性支气管肺癌并伴有脑转移。他接受了开颅减压手术，目前正在接受化疗。该病例需要协作努力以诊断脑转移，以及组织病理学对于确诊脑转移的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/cc361c3cc0fb/cureus-0016-00000068035-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/0957a6527fc4/cureus-0016-00000068035-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/72d793c99267/cureus-0016-00000068035-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/57502ab0a9ed/cureus-0016-00000068035-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/4ee2c7a297de/cureus-0016-00000068035-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/279b7a20a131/cureus-0016-00000068035-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/29e67055468d/cureus-0016-00000068035-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/cc361c3cc0fb/cureus-0016-00000068035-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/0957a6527fc4/cureus-0016-00000068035-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/72d793c99267/cureus-0016-00000068035-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/57502ab0a9ed/cureus-0016-00000068035-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/4ee2c7a297de/cureus-0016-00000068035-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/279b7a20a131/cureus-0016-00000068035-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/29e67055468d/cureus-0016-00000068035-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030a/11432779/cc361c3cc0fb/cureus-0016-00000068035-i07.jpg

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本文引用的文献

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Small-cell lung cancer brain metastasis: From molecular mechanisms to diagnosis and treatment.小细胞肺癌脑转移：从分子机制到诊断与治疗。
Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1;1868(12):166557. doi: 10.1016/j.bbadis.2022.166557. Epub 2022 Sep 24.
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2021 WHO classification of tumours of the central nervous system: a review for the neuroradiologist.2021 年世界卫生组织中枢神经系统肿瘤分类：神经放射学家的复习指南。
Neuroradiology. 2022 Oct;64(10):1919-1950. doi: 10.1007/s00234-022-03008-6. Epub 2022 Jul 22.
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Distribution Of Brain Metastasis From Lung Cancer.
肺癌脑转移的分布
Cancer Manag Res. 2019 Nov 1;11:9331-9338. doi: 10.2147/CMAR.S222920. eCollection 2019.
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State-of-the-art considerations in small cell lung cancer brain metastases.小细胞肺癌脑转移的最新考量
Oncotarget. 2017 Jul 18;8(41):71223-71233. doi: 10.18632/oncotarget.19333. eCollection 2017 Sep 19.
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The molecular biology of lung cancer brain metastasis: an overview of current comprehensions and future perspectives.肺癌脑转移的分子生物学：当前认识与未来展望综述
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E-cadherin as a predictive marker of brain metastasis in non-small-cell lung cancer, and its regulation by pioglitazone in a preclinical model.E-钙黏蛋白作为非小细胞肺癌脑转移的预测标志物，及其在临床前模型中被吡格列酮调控。
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