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上皮样炎性肌纤维母细胞肉瘤：1例罕见病例报告

Epithelioid Inflammatory Myofibroblastic Sarcoma: A Report of a Rare Case.

作者信息

Ronanki Varun, Tejeswini Vaddatti, Venkata Renuka Inuganti, Raheema Shaik, S K Kanth Bakkamanthala

机构信息

Pathology, NRI Medical College, Guntur, IND.

出版信息

Cureus. 2024 Aug 30;16(8):e68184. doi: 10.7759/cureus.68184. eCollection 2024 Aug.

DOI:10.7759/cureus.68184
PMID:39347189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11439187/
Abstract

Epithelioid inflammatory myofibroblastic sarcoma (EIMS), a variant of inflammatory myofibroblastic tumor (IMT), is a rare malignant tumor commonly associated with anaplastic lymphoma kinase (ALK) gene fusions and is aggressive in nature with local recurrence. Here, we report a case of a 23-year-old female who presented with a cough and, upon investigations, was found to have a mass in the left upper lobe of the lung detected by chest computed tomography (CT). Biopsy revealed EIMS with ALK and desmin protein expression. The patient underwent a lobectomy via video-assisted thoracoscopic surgery (VATS). The postoperative period was uneventful.

摘要

上皮样炎性肌纤维母细胞肉瘤（EIMS）是炎性肌纤维母细胞瘤（IMT）的一种变体，是一种罕见的恶性肿瘤，通常与间变性淋巴瘤激酶（ALK）基因融合相关，具有侵袭性，易局部复发。在此，我们报告一例23岁女性病例，该患者因咳嗽就诊，经检查，胸部计算机断层扫描（CT）发现左肺上叶有一肿块。活检显示为伴有ALK和结蛋白蛋白表达的EIMS。患者接受了电视辅助胸腔镜手术（VATS）下的肺叶切除术。术后恢复顺利。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/c872744a75ae/cureus-0016-00000068184-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/d83f528e6d7f/cureus-0016-00000068184-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/6aaa914382ec/cureus-0016-00000068184-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/3752e6ffdab6/cureus-0016-00000068184-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/221a09d3d056/cureus-0016-00000068184-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/a8733c1e7764/cureus-0016-00000068184-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/ac5e8f1d278a/cureus-0016-00000068184-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/0ecbddb6e974/cureus-0016-00000068184-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/c872744a75ae/cureus-0016-00000068184-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/d83f528e6d7f/cureus-0016-00000068184-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/6aaa914382ec/cureus-0016-00000068184-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/3752e6ffdab6/cureus-0016-00000068184-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/221a09d3d056/cureus-0016-00000068184-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/a8733c1e7764/cureus-0016-00000068184-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/ac5e8f1d278a/cureus-0016-00000068184-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/0ecbddb6e974/cureus-0016-00000068184-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7591/11439187/c872744a75ae/cureus-0016-00000068184-i08.jpg

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本文引用的文献

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Front Oncol. 2023 Sep 29;13:1212529. doi: 10.3389/fonc.2023.1212529. eCollection 2023.
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Epithelioid Inflammatory Myofibroblastic Sarcoma Presenting as Gastrointestinal Bleed: Case Report and Literature Review.以胃肠道出血为表现的上皮样炎性肌纤维母细胞肉瘤：病例报告及文献复习
JPGN Rep. 2020 Dec 17;2(1):e019. doi: 10.1097/PG9.0000000000000019. eCollection 2021 Feb.
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Case report: Epithelioid inflammatory myofibroblastic sarcoma treated with an ALK TKI ensartinib.
病例报告：用ALK酪氨酸激酶抑制剂恩沙替尼治疗上皮样炎性肌纤维母细胞肉瘤。
Front Oncol. 2023 Mar 22;13:1084456. doi: 10.3389/fonc.2023.1084456. eCollection 2023.
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Primary pulmonary epithelioid inflammatory myofibroblastic sarcoma: a rare entity and a literature review.原发性肺上皮样炎性肌纤维母细胞肉瘤：一种罕见疾病及文献综述
J Pathol Transl Med. 2022 Jul;56(4):231-237. doi: 10.4132/jptm.2022.05.08. Epub 2022 Jul 7.
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Primary Cutaneous Epithelioid Inflammatory Myofibroblastic Sarcoma Harboring RANBP2-ALK Fusion: Report of an Exceptional Case.携带RANBP2-ALK融合基因的原发性皮肤上皮样炎性肌纤维母细胞肉瘤：1例罕见病例报告
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