Amaeshi Lemchukwu, Kalejaiye Olufunto O, Olopade Oluwarotimi B, Kehinde Michael
Clinical Hematology, Internal Medicine, Lagos University Teaching Hospital, Lagos, NGA.
Clinical Hematology, Internal Medicine, College of Medicine, University of Lagos and Lagos University Teaching Hospital, Lagos, NGA.
Cureus. 2024 Aug 30;16(8):e68186. doi: 10.7759/cureus.68186. eCollection 2024 Aug.
Hematologic inflammatory biomarkers derived from a full blood count (FBC) are elevated in Type 2 diabetes mellitus (DM). In low- and middle-income countries like Nigeria, a FBC is an affordable and easily available test, even in rural areas. Glycated hemoglobin (HbA1c), a measure of glycemic control, has been found to correlate with hematologic inflammatory markers. In Nigeria, where health care is expensive and patients essentially pay out of pocket, a more affordable and accessible alternative to HbA1c in determining glycemic control is needed. Therefore, this study aimed to determine the relationship between Hb A1c and hematologic inflammatory biomarkers, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and mean platelet volume (MPV), in predicting glycemic control.
This was a six-month study of 109 patients with Type 2 DM in a tertiary hospital in Lagos. The patients' HbA1c and FBC were measured. NLR, PLR, and MPV were derived from the FBC values. We categorized the patients based on glycemic control. Spearman correlation analysis was used to determine the relationship between HbA1c and the inflammatory biomarkers.
There was no significant difference in NLR, PLR, and MPV between optimal and suboptimal controlled diabetic patients. Spearman's correlation analysis showed no significant association between NLR, PLR, MPV, and HbA1c in the patients (NLR: r=0.027, P=0.680; PLR: r=-0.091, P=0.356; MPV: r=-0.032, P=0.744).
The inflammatory markers studied had no significant relationship with HbA1c and might not help monitor glycemic control in Type 2 DM patients.
全血细胞计数（FBC）得出的血液学炎症生物标志物在2型糖尿病（DM）中会升高。在尼日利亚这样的低收入和中等收入国家，即使在农村地区，全血细胞计数也是一项价格亲民且易于获得的检测。糖化血红蛋白（HbA1c）是血糖控制的一项指标，已发现其与血液学炎症标志物相关。在尼日利亚，医疗费用高昂，患者基本需自掏腰包，因此需要一种在确定血糖控制方面比HbA1c更经济实惠且易于获取的替代方法。因此，本研究旨在确定HbA1c与血液学炎症生物标志物、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）以及平均血小板体积（MPV）在预测血糖控制方面的关系。
这是一项在拉各斯一家三级医院对109例2型糖尿病患者进行的为期六个月的研究。测量了患者的HbA1c和全血细胞计数。NLR、PLR和MPV由全血细胞计数的值得出。我们根据血糖控制情况对患者进行了分类。采用Spearman相关性分析来确定HbA1c与炎症生物标志物之间的关系。
血糖控制最佳和欠佳的糖尿病患者在NLR、PLR和MPV方面没有显著差异。Spearman相关性分析显示，患者的NLR、PLR、MPV与HbA1c之间没有显著关联（NLR：r = 0.027，P = 0.680；PLR：r = -0.091，P = 0.356；MPV：r = -0.032，P = 0.744）。
所研究的炎症标志物与HbA1c没有显著关系，可能无助于监测2型糖尿病患者的血糖控制。
