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利培酮致分裂情感性障碍患者尿失禁1例报告

Risperidone-Induced Urinary Incontinence in Schizoaffective Disorder: A Case Report.

作者信息

Almaazmi Bashayer M, Rex Pearl, Aldweik Abdullah N, Mukhtar Mazin A

机构信息

Psychiatry, Al Amal Psychiatric Hospital, Dubai, ARE.

Medicine, University of Sharjah, Sharjah, ARE.

出版信息

Cureus. 2024 Aug 29;16(8):e68121. doi: 10.7759/cureus.68121. eCollection 2024 Aug.

Abstract

Risperidone is a widely used atypical antipsychotic known for its efficacy in managing various psychiatric conditions. However, it is not without adverse effects, and one such underreported side effect is that of urinary incontinence. This case report highlights the experience of a 59-year-old gentleman with a diagnosis of schizoaffective disorder who, after being admitted due to a relapse of his symptoms, developed urinary incontinence with risperidone. The patient's symptoms resolved upon the gradual reduction of the risperidone dose to 2 mg at bedtime. Urinary incontinence as a side effect of antipsychotics has been documented in children, especially in those with autism or developmental disorders, but there is limited research on its occurrence in adults. Urinary incontinence can have significant social and psychological impacts on patients, leading to feelings of embarrassment and social withdrawal. It can also contribute to treatment non-adherence leading to frequent relapses and exacerbations of psychiatric symptoms. In managing patients with risperidone-induced urinary incontinence, it is essential to explore medical causes thoroughly before considering medication changes. Behavioral modifications such as bladder training, biofeedback, and lifestyle modifications can also be effective in reducing the frequency of incontinence episodes. This case report emphasizes the importance of prompt identification and intervention to minimize the debilitating effects of urinary incontinence on patients with psychiatric conditions.

摘要

利培酮是一种广泛使用的非典型抗精神病药物,以其在治疗各种精神疾病方面的疗效而闻名。然而,它并非没有副作用,其中一种未被充分报道的副作用是尿失禁。本病例报告突出了一名59岁被诊断为精神分裂症的男性患者的经历,该患者因症状复发入院后,服用利培酮出现了尿失禁。当利培酮剂量逐渐减至睡前2毫克时,患者的症状得到缓解。抗精神病药物导致尿失禁作为副作用在儿童中已有记录,尤其是在患有自闭症或发育障碍的儿童中,但关于其在成人中发生情况的研究有限。尿失禁会对患者产生重大的社会和心理影响,导致尴尬和社交退缩感。它还可能导致治疗依从性差,进而导致精神症状频繁复发和加重。在处理利培酮引起的尿失禁患者时,在考虑改变药物治疗之前,彻底探究医学原因至关重要。行为改变,如膀胱训练、生物反馈和生活方式改变,也可以有效地减少尿失禁发作的频率。本病例报告强调了及时识别和干预的重要性,以尽量减少尿失禁对精神疾病患者的致残影响。

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本文引用的文献

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A Case of Risperidone-Induced Urinary Incontinence.一例利培酮所致尿失禁病例。
Cureus. 2024 Apr 19;16(4):e58590. doi: 10.7759/cureus.58590. eCollection 2024 Apr.
2
Metabolic Adverse Effects of Psychotropic Drug Therapy: A Systematic Review.精神药物治疗的代谢不良反应:一项系统综述。
Eur J Investig Health Psychol Educ. 2023 Aug 12;13(8):1505-1520. doi: 10.3390/ejihpe13080110.
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Paliperidone Palmitate-induced Urinary Incontinence: A Case Report.棕榈酸帕利哌酮致尿失禁:一例报告
Clin Psychopharmacol Neurosci. 2016 Feb 29;14(1):96-100. doi: 10.9758/cpn.2016.14.1.96.
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Nocturnal enuresis with antipsychotic medication.抗精神病药物引起的夜间遗尿症。
Br J Psychiatry. 2012 Jan;200(1):7-9. doi: 10.1192/bjp.bp.111.095737.

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