Abdullah Baharudin, Koh Kar Chai, Mohamed Mohazmi, Tan Vincent Eng Soon, Mohammad Nurashikin, Sekawi Zamberi, Periyasamy Petrick, Ramadas Anitha, Duerden Martin
School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Kepong Baru Polyclinic, Kuala Lumpur, Malaysia.
Infect Drug Resist. 2024 Sep 24;17:4149-4160. doi: 10.2147/IDR.S477038. eCollection 2024.
Using antibiotics in the treatment of acute sore throats has been linked with antimicrobial resistance (AMR) and needs to be addressed. The consensus sought to improve diagnostic accuracy, decrease unwarranted antibiotic prescriptions and enhance patient outcomes.
A multidisciplinary panel of nine experts reviewed published literature and discussed current practices in managing sore throat. Ten evidence-based statements on sore throat and AMR, diagnostic accuracy and antibiotic prescribing, and symptomatic therapy were developed. A modified Delphi exercise was then carried out. A consensus was reached if at least 70% of the group agreed with the statement.
All 10 statements for managing acute sore throat achieved consensus. The major concern of AMR caused by improper antibiotic prescribing, particularly in cases of viral sore throat, was recognized. This underscores the need for improved diagnostic tools, such as the McIsaac score, to reduce needless antibiotic prescriptions. To improve patient satisfaction, effective pain management using non-antibiotic alternatives such as paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs), and flurbiprofen throat lozenges was recommended. Pain and inflammation can be adequately managed with low-dose NSAIDs. The potential benefits of topical NSAIDs were acknowledged for their milder safety profile than oral formulations.
A consensus was achieved on the use of a clinical diagnostic tool, prudent use of antibiotics, and symptomatic therapy in acute sore throat management. The McIsaac score and point-of-care testing (POCT) for the presence of group A beta-hemolytic (GABHS) can aid in the decision-making process for antibiotic use, reducing needless prescriptions. The mainstay of therapy is symptomatic treatment, which includes the use of NSAIDs.
在急性咽喉痛治疗中使用抗生素与抗菌药物耐药性(AMR)相关,这一问题需要得到解决。该共识旨在提高诊断准确性、减少不必要的抗生素处方并改善患者治疗效果。
一个由九名专家组成的多学科小组回顾了已发表的文献,并讨论了当前咽喉痛管理的实践。制定了关于咽喉痛与AMR、诊断准确性和抗生素处方以及对症治疗的十条循证声明。然后进行了一次改良的德尔菲法。如果至少70%的小组成员同意该声明,则达成共识。
关于急性咽喉痛管理的所有十条声明均达成共识。人们认识到不当使用抗生素,尤其是在病毒性咽喉痛病例中,会导致AMR这一主要问题。这凸显了改进诊断工具(如麦基萨克评分)以减少不必要抗生素处方的必要性。为了提高患者满意度,建议使用对乙酰氨基酚、非甾体抗炎药(NSAIDs)和氟比洛芬含片等非抗生素替代品进行有效的疼痛管理。低剂量NSAIDs可充分控制疼痛和炎症。局部使用NSAIDs因其安全性比口服制剂更温和而被认可具有潜在益处。
在急性咽喉痛管理中使用临床诊断工具、谨慎使用抗生素和对症治疗方面达成了共识。用于检测A组β溶血性链球菌(GABHS)的麦基萨克评分和即时检验(POCT)有助于抗生素使用的决策过程,减少不必要的处方。治疗的主要方法是对症治疗,包括使用NSAIDs。