痴呆症护理的实用临床试验：IMPACT合作实验室头5年的经验
Pragmatic Clinical Trials for Dementia Care: Experience from the First 5 Years of the IMPACT Collaboratory.
作者信息
Harrison Jill, Mitchell Susan L, McCarthy Ellen P, Mor Vincent
机构信息
NIA IMPACT Collaboratory and associate professor of the Practice at Brown University, School of Public Health in Providence, RI.
NIA IMPACT Collaboratory, a senior scientist at the Marcus Institute for Aging Research, Hebrew SeniorLife, and a professor of Medicine at Harvard Medical School in Cambridge, MA.
出版信息
Generations. 2024 Summer;48(2). Epub 2024 Jun 26.
Abstract
The IMPACT Collaboratory is a national infrastructure and resource dedicated to transforming dementia care in real-world environments for millions of Americans and their care partners, using embedded pragmatic clinical trials. This new approach of applied clinical research holds the promise of accelerating the science of dementia care, improving relevancy of interventions to real-world partners, promoting health equity, and closing the gaps between research, everyday clinical practice, and lived experiences of people living with dementia and their care partners.
摘要
IMPACT合作实验室是一个国家基础设施和资源机构，致力于通过嵌入式实用临床试验，在现实环境中为数百万美国人和他们的护理伙伴改变痴呆症护理方式。这种应用临床研究的新方法有望加速痴呆症护理科学的发展，提高干预措施与现实世界伙伴的相关性，促进健康公平，并缩小研究、日常临床实践以及痴呆症患者及其护理伙伴的生活经历之间的差距。
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本文引用的文献
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Alzheimers Dement. 2023 Apr;19(4):1598-1695. doi: 10.1002/alz.13016. Epub 2023 Mar 14.
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Transforming Dementia Care Through Pragmatic Clinical Trials Embedded in Learning Healthcare Systems.通过嵌入学习型医疗保健系统的实用临床试验来改变痴呆症护理。
J Am Geriatr Soc. 2020 Jul;68 Suppl 2(Suppl 2):S43-S48. doi: 10.1111/jgs.16629.
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Achieving Health Equity in Embedded Pragmatic Trials for People Living with Dementia and Their Family Caregivers.实现与痴呆症患者及其家庭照护者共同生活的人群参与的嵌入式实用临床试验中的健康公平。
J Am Geriatr Soc. 2020 Jul;68 Suppl 2(Suppl 2):S8-S13. doi: 10.1111/jgs.16614.
6
Embedded Pragmatic Trials in Dementia Care: Realizing the Vision of the NIA IMPACT Collaboratory.痴呆症护理中的嵌入式实用临床试验：实现 NIA IMPACT 协作研究的愿景。
J Am Geriatr Soc. 2020 Jul;68 Suppl 2(Suppl 2):S1-S7. doi: 10.1111/jgs.16621.
7
Selecting Outcomes to Ensure Pragmatic Trials Are Relevant to People Living with Dementia.选择结局指标以确保痴呆患者参与的实用临床试验具有相关性。
J Am Geriatr Soc. 2020 Jul;68 Suppl 2(Suppl 2):S55-S61. doi: 10.1111/jgs.16619.
8
Engaging Stakeholders in the Design and Conduct of Embedded Pragmatic Clinical Trials for Alzheimer's Disease and Alzheimer's Disease-Related Dementias.参与阿尔茨海默病和阿尔茨海默病相关痴呆症嵌入式实用临床试验的设计和实施。
J Am Geriatr Soc. 2020 Jul;68 Suppl 2(Suppl 2):S62-S67. doi: 10.1111/jgs.16630.
9
Comparative Efficacy of Interventions for Aggressive and Agitated Behaviors in Dementia: A Systematic Review and Network Meta-analysis.干预措施在痴呆症激越和激越行为中的比较疗效：系统评价和网络荟萃分析。
Ann Intern Med. 2019 Nov 5;171(9):633-642. doi: 10.7326/M19-0993. Epub 2019 Oct 15.
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Readiness assessment for pragmatic trials (RAPT): a model to assess the readiness of an intervention for testing in a pragmatic trial.实用临床试验准备度评估（RAPT）：用于评估干预措施在实用临床试验中测试准备度的模型。
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