Centre for Quality Management of Medicines, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia.
Faculty of Pharmacy, Universitas Airlangga, PQMM+9Q6, Gedung Nanizar Zaman Joenoes Kampus C UNAIR, Jl. Mulyorejo, Mulyorejo, Surabaya, East Java, 60115, Indonesia.
Pharmacogenomics. 2024;25(10-11):479-494. doi: 10.1080/14622416.2024.2403969. Epub 2024 Sep 30.
To summarize the effects of single nucleotide polymorphisms (SNPs) on the pharmacokinetics of allopurinol to control uric acid levels. A comprehensive search was conducted in PubMed, Web of Science and Scopus databases from inception to January 2024, includes 17 articles focusing on SNPs and pharmacokinetics of allopurinol and oxypurinol. A total of 11 SNPs showed a significant association with pharmacokinetics of allopurinol and oxypurinol, as well as their potential clinical implications. SNPs in ATP-binding cassette super-family G member 2 (), solute carrier family 2 member 9 (), solute carrier family 17 member 1 (), solute carrier family 22 member 12 (), solute carrier family 22 member 13 () and PDZ domain containing 1 () genes were associated with allopurinol clearance, while SNPs in aldehyde oxidase 1 () genes involved in metabolism of allopurinol. SNPs in gremlin 2, DAN family BMP antagonist () gene impacted uric acid control, but the specific mechanism governing the expression of remains unknown. Our study indicated that the identified SNPs show contradictory effects, reflecting inconsistencies and differences observed across various studies.
总结单核苷酸多态性（SNPs）对别嘌醇药代动力学的影响，以控制尿酸水平。从建库到 2024 年 1 月，我们在 PubMed、Web of Science 和 Scopus 数据库中进行了全面检索，共纳入 17 篇关注别嘌醇及其代谢产物氧嘌呤醇的 SNPs 与药代动力学的文章。共有 11 个 SNPs 与别嘌醇和氧嘌呤醇的药代动力学及其潜在的临床意义显著相关。ATP 结合盒超家族 G 成员 2（）、溶质载体家族 2 成员 9（）、溶质载体家族 17 成员 1（）、溶质载体家族 22 成员 12（）、溶质载体家族 22 成员 13（）和 PDZ 结构域包含蛋白 1（）基因中的 SNPs 与别嘌醇清除率相关，而醛氧化酶 1（）基因中的 SNPs 参与别嘌醇的代谢。Gremlin 2、DAN 家族 BMP 拮抗剂（）基因中的 SNPs 影响尿酸的控制，但调控其表达的具体机制尚不清楚。我们的研究表明，已确定的 SNPs 显示出相互矛盾的作用，反映了不同研究中观察到的不一致性和差异。
