Beckman Laser Institute Korea, Dankook University, Cheonan, Republic of Korea.
Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University, Cheonan, Republic of Korea.
Photobiomodul Photomed Laser Surg. 2024 Nov;42(11):663-667. doi: 10.1089/photob.2024.0097. Epub 2024 Sep 30.
Photobiomodulation (PBM) is a noninvasive therapeutic modality with widespread applications for modulating various biological processes. Although the exact mechanisms of action remain uncertain, PBM promotes homeostasis through diverse pathways, including reducing inflammation and enhancing tissue recovery. Hearing loss is irreversible in mammals due to the limited regenerative capacity of cochlear hair cells. Cochlear implants offer a solution by electrically stimulating the auditory nerve, bypassing damaged hair cells in individuals with severe hearing loss. However, postoperative inflammatory responses and cochlear nerve fiber damage can compromise implant efficacy. We investigated current strategies to minimize secondary cochlear damage after cochlear implantation and evaluated the potential of PBM as an adjuvant therapeutic approach. The auditory cell protective effects of PBM could significantly enhance the performance of EAS devices in individuals with residual hearing. Further, postoperative CI is accompanied by an inflammatory response characterized by the upregulation of specific cytokines. Considering the neuroregenerative potential of PBM, its application as a neuroprotective strategy warrants further validation.
光生物调节（PBM）是一种非侵入性的治疗方式，广泛应用于调节各种生物过程。虽然确切的作用机制尚不清楚，但 PBM 通过多种途径促进内稳态，包括减少炎症和增强组织恢复。哺乳动物的听力损失是不可逆转的，因为耳蜗毛细胞的再生能力有限。耳蜗植入物通过电刺激听神经为严重听力损失的个体提供了一种解决方案，绕过受损的毛细胞。然而，术后炎症反应和耳蜗神经纤维损伤会影响植入物的疗效。我们研究了目前最小化耳蜗植入后二次耳蜗损伤的策略，并评估了 PBM 作为辅助治疗方法的潜力。PBM 的听觉细胞保护作用可以显著提高残余听力个体中 EAS 装置的性能。此外，术后 CI 伴随着炎症反应，其特征是特定细胞因子的上调。鉴于 PBM 的神经再生潜力，将其作为神经保护策略应用值得进一步验证。
