The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Department of Neurology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Br J Hosp Med (Lond). 2024 Sep 30;85(9):1-14. doi: 10.12968/hmed.2024.0386.
The systemic inflammatory response index (SIRI), an emerging hematological marker of inflammation, has shown promise as a promising biomarker for a variety of inflammatory conditions. This study aims to explore the diagnostic role of SIRI in Bell's palsy (BP). For this retrospective study, 73 people diagnosed with BP between January 2021 and December 2023 were recruited, along with 73 healthy controls who were age- and sex-matched. The SIRI and other blood inflammatory markers, including the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), were determined for all participants, by enumerating their peripheral blood cell counts. Facial nerve function was assessed upon admission and after one month of treatment using the House-Brackmann Facial Nerve Grading System (H-B). According to this system, patients with an H-B grade of 1-2 are considered recovered, while those with an H-B grade of 3-6 are regarded as not recovered. The SIRI (0.94 vs 0.48, < 0.001), SII (480.3 vs 329.12, < 0.001), NLR (2.42 vs 1.41, < 0.001), and PLR (141.05 vs 117.28, = 0.001) showed a significant increase in the BP group compared to the control group. The receiver operating characteristic (ROC) curve analysis revealed that the area under the curve (AUC) for SIRI was higher than those for SII, NLR, and PLR, respectively. Upon one-month follow-up, significant differences in the values of SIRI, SII, and NLR were observed between the favorable prognosis group and the poor prognosis group (SIRI: 1.07 vs 0.87, = 0.011; SII: 647.85 vs 422.11, = 0.005; NLR: 3.31 vs 2.11, = 0.013). The AUC of ROC curve for SIRI was found to be lower than that of SII but higher than that of NLR. The SIRI has the potential to be an important BP diagnostic and prognostic marker.
系统性炎症反应指数（SIRI）是一种新兴的炎症血液标志物，已被证明是多种炎症疾病的有前途的生物标志物。本研究旨在探讨 SIRI 在贝尔面瘫（BP）中的诊断作用。
在这项回顾性研究中，招募了 73 名在 2021 年 1 月至 2023 年 12 月期间被诊断为 BP 的患者和 73 名年龄和性别匹配的健康对照组。通过计数外周血细胞计数，确定了所有参与者的 SIRI 和其他血液炎症标志物，包括系统免疫炎症指数（SII）、中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）。
入院时和治疗一个月后，使用 House-Brackmann 面神经分级系统（H-B）评估面神经功能。根据该系统，H-B 分级为 1-2 的患者被认为已恢复，而 H-B 分级为 3-6 的患者则被视为未恢复。
与对照组相比，BP 组的 SIRI（0.94 对 0.48， < 0.001）、SII（480.3 对 329.12， < 0.001）、NLR（2.42 对 1.41， < 0.001）和 PLR（141.05 对 117.28， = 0.001）均显著升高。受试者工作特征（ROC）曲线分析显示，SIRI 的曲线下面积（AUC）高于 SII、NLR 和 PLR。在一个月的随访中，在预后良好组和预后不良组之间观察到 SIRI、SII 和 NLR 值存在显著差异（SIRI：1.07 对 0.87， = 0.011；SII：647.85 对 422.11， = 0.005；NLR：3.31 对 2.11， = 0.013）。SIRI 的 ROC 曲线 AUC 低于 SII，但高于 NLR。
SIRI 有望成为 BP 的重要诊断和预后标志物。
