与药物超敏反应综合征相关的双侧类Purtscher样视网膜病变：一例报告
Bilateral purtscher-like retinopathy associated with DRESS syndrome: a case report.
作者信息
Yuan Langxuan, Li Yuchen, Zhang Hanze, Hou Yucen, Kang Qianyan, Lei Jianqin
机构信息
Department of Ophthalmology, First Affiliated Hospital of Xi'an Jiaotong University, 277# west Yan Ta road, Xi'an, Shaanxi, 710061, China.
出版信息
J Ophthalmic Inflamm Infect. 2024 Sep 30;14(1):46. doi: 10.1186/s12348-024-00433-x.
BACKGROUND
To report a case of Bilateral Purtscher-like retinopathy associated with DRESS syndrome managed with ocular and systemic treatments.
CASE PRESENTATION
A 29-year-old healthy female developed multi-organ (cutaneous, hematologic, renal and hepatic) disfunction and profound vision loss 1 month after Human papillomavirus vaccine injection. At the first presentation, her visual acuity was counting fingers in both eyes. Fundus exam showed remarkable cotton-wool spots, retinal hemorrhages and macular edema. She was diagnosed DRESS syndrome and Purtscher-like retinopathy and treated with intravitreal injection of ranibizumab, systemic steroids anticoagulants, and plasma exchange. The patient finally recovered from this life-threatening condition but left with permanent visual damage.
CONCLUSION
Purtscher-like retinopathy could be complicated by DRESS syndrome which is usually considered a type IV hypersensitivity reaction.
背景
报告一例与药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征相关的双侧普-罗二氏样视网膜病变，采用眼部和全身治疗。
病例介绍
一名29岁健康女性在接种人乳头瘤病毒疫苗1个月后出现多器官（皮肤、血液、肾脏和肝脏）功能障碍及严重视力丧失。初诊时，她双眼视力为指数。眼底检查显示有明显的棉絮斑、视网膜出血和黄斑水肿。她被诊断为DRESS综合征和普-罗二氏样视网膜病变，并接受了玻璃体内注射雷珠单抗、全身使用类固醇、抗凝剂和血浆置换治疗。患者最终从这种危及生命的疾病中康复，但留下了永久性视力损害。
结论
普-罗二氏样视网膜病变可能并发DRESS综合征，后者通常被认为是一种IV型超敏反应。
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