Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, 20100, Italy.
Unit of Endocrinology, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3, Milan, 20162, Italy.
J Endocrinol Invest. 2024 Dec;47(12):2929-2942. doi: 10.1007/s40618-024-02440-0. Epub 2024 Sep 30.
Recent studies investigated the prevalence of arterial hypertension (AH), diabetes mellitus (DM) and/or prediabetes, dyslipidemia (DL), metabolic syndrome (MS) and cardiovascular events (CVE) in patients with non-functioning adrenal incidentalomas (NFAI). We aimed to investigate the available literature to determine the prevalence of AH, DM, DM and/or prediabetes (Composite DM, C-DM), DL, MS and CVE in patients with NFAI as compared to patients without adrenal incidentalomas (AI).
Systematic review and meta-analysis.
A meta-analysis was performed using studies that evaluated the prevalence of AH, DM, C-DM, DL, MS and CVE in patients with NFAI versus matched subjects without AI. A random-effects model (DerSimonian and Laird) was used to calculate the pooled odds ratio (OR) and 95% Confidence Interval (95%CI) for each outcome.
Among the 36 available studies, 19 studies provided the necessary data (4716 subjects, mean age 57.6 ± 4.6). The association between AH, DM, C-DM, DL, MS and CVE was reported in 18 (4546 subjects), 7 (1743 subjects), 5 (4315 subjects), 11 (3820 subjects), 8 (1170 subjects) and 5 (2972 subjects), respectively. The presence of NFAI was associated with AH (OR 1.87, 95%CI 1.39-2.51), C-DM (OR 2.04, 95%CI 1.70-2.45) and MS (OR 2.89, 95%CI 1.93-4.32), but not with DM, DL and CVE.
Patients with NFAI have higher prevalence of AH, C-DM and MS than control subjects without NFAI.
最近的研究调查了无功能肾上腺意外瘤（NFAI）患者中动脉高血压（AH）、糖尿病（DM）和/或糖尿病前期、血脂异常（DL）、代谢综合征（MS）和心血管事件（CVE）的患病率。我们旨在调查现有文献，以确定与无肾上腺意外瘤（AI）患者相比，NFAI 患者中 AH、DM、DM 和/或糖尿病前期（复合 DM，C-DM）、DL、MS 和 CVE 的患病率。
系统评价和荟萃分析。
使用评估 NFAI 患者与无 AI 匹配对照者中 AH、DM、C-DM、DL、MS 和 CVE 患病率的研究进行荟萃分析。使用随机效应模型（DerSimonian 和 Laird）计算每个结局的汇总优势比（OR）和 95%置信区间（95%CI）。
在 36 项可用研究中，有 19 项研究提供了必要的数据（4716 例患者，平均年龄 57.6±4.6）。AH、DM、C-DM、DL、MS 和 CVE 之间的关联在 18 项（4546 例患者）、7 项（1743 例患者）、5 项（4315 例患者）、11 项（3820 例患者）、8 项（1170 例患者）和 5 项（2972 例患者）中得到了报道。NFAI 的存在与 AH（OR 1.87，95%CI 1.39-2.51）、C-DM（OR 2.04，95%CI 1.70-2.45）和 MS（OR 2.89，95%CI 1.93-4.32）相关，但与 DM、DL 和 CVE 无关。
与无 NFAI 的对照者相比，NFAI 患者 AH、C-DM 和 MS 的患病率更高。
