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一个专门的多肌痛快速诊疗门诊的真实世界疗效

Real-world outcomes of a dedicated fast-track polymyalgia rheumatica clinic.

作者信息

Cowley Sharon, Harkins Patricia, Kirby Colm, Conway Richard, Kane David

机构信息

Department of Rheumatology, Tallaght University Hospital, Dublin, Ireland.

School of Medicine, Trinity College Dublin, Dublin, Ireland.

出版信息

Rheumatology (Oxford). 2025 May 1;64(5):3006-3011. doi: 10.1093/rheumatology/keae531.

Abstract

OBJECTIVES

To examine the clinical impact of a fast-track PMR clinic to enable early diagnosis and treatment, and to define both patient and disease characteristics in newly diagnosed PMR.

METHODS

Primary care physicians were invited to refer patients with new PMR to our fast-track clinic. Referral criteria included new onset shoulder or pelvic girdle pain and/or stiffness with elevated inflammatory markers in patients over 50 years. All patients were seen within 72 h of referral. Patients with a rheumatology diagnosis of PMR had an US of their temporal and axillary arteries.

RESULTS

172 patients were referred from primary care over 12 months. 39% of patients referred with suspected PMR had an alternative diagnosis for which PMR regimen glucocorticoids was inappropriate. 55% of the non-PMR diagnoses were other inflammatory rheumatological conditions requiring follow-up. Only 20% of patients referred from primary care already on glucocorticoids were commenced on bone protection. PMR patients were comorbid, with a mean of 2.5 other conditions. 75% of PMR patients experienced a glucocorticoid-related adverse event in the first 12 months of treatment. 17% of patients with new PMR had US features of subclinical GCA.

CONCLUSION

The commencement of glucocorticoid therapy should be deferred until after specialist evaluation to enable an accurate clinical diagnosis. A delay in treatment can only realistically be avoided if general practitioners have access to a fast-track PMR clinic. We believe that rheumatologists should consider establishing fast-track PMR clinics and this study provides a strong case for and a template to support this practice innovation.

摘要

目的

探讨快速通道颞动脉炎门诊对实现早期诊断和治疗的临床影响,并明确新诊断颞动脉炎患者的患者特征和疾病特征。

方法

邀请基层医疗医生将新诊断为颞动脉炎的患者转诊至我们的快速通道门诊。转诊标准包括50岁以上患者新发肩部或骨盆带疼痛和/或僵硬,且炎症标志物升高。所有患者在转诊后72小时内就诊。确诊为颞动脉炎的患者接受颞动脉和腋动脉超声检查。

结果

12个月内有172例患者从基层医疗转诊而来。因疑似颞动脉炎转诊的患者中,39%有其他诊断,不适用于颞动脉炎治疗方案中的糖皮质激素。非颞动脉炎诊断中有55%为其他需要随访的炎性风湿性疾病。从基层医疗转诊而来且已在使用糖皮质激素的患者中,只有20%开始进行骨保护治疗。颞动脉炎患者合并多种疾病,平均合并2.5种其他疾病。75%的颞动脉炎患者在治疗的前12个月出现了与糖皮质激素相关的不良事件。17%的新诊断颞动脉炎患者有亚临床巨细胞动脉炎的超声特征。

结论

糖皮质激素治疗应推迟到专科评估后进行,以实现准确临床诊断。只有当全科医生能够使用快速通道颞动脉炎门诊时,才能切实避免治疗延误。我们认为,风湿病学家应考虑设立快速通道颞动脉炎门诊,本研究为支持这一实践创新提供了有力依据和模板。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12af/12048043/16fec8857050/keae531f1.jpg

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