Fu Qian-Qian, Liang Yuan, Sun Xiao-Xiao, Chu Xue-Qiang, Xu Hao, Zhou Xiaocong, Rao Weidong, Shen Zhi-Liang
Technical Institute of Fluorochemistry (TIF), School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.
College of Biological, Chemical Science and Engineering, Jiaxing University, 118 Jiahang Road, Jiaxing 314001, China.
Org Lett. 2024 Oct 11;26(40):8577-8582. doi: 10.1021/acs.orglett.4c03208. Epub 2024 Sep 30.
We report here a step-economic and cost-effective cross-electrophile coupling of aryl thianthrenium salts with widely available aryl bromides, which proceeded effectively via C-S bond activation at ambient temperature in THF in the presence of a palladium catalyst, magnesium turnings, and lithium chloride to enable the facile assembly of a wide array of structurally diverse biaryls in modest to good yields with good functional group compatibility. In addition, the gram-scale reaction could also be realized.
我们在此报道了一种步骤经济且具有成本效益的芳基噻蒽鎓盐与广泛可得的芳基溴化物的交叉亲电偶联反应。该反应在钯催化剂、镁屑和氯化锂存在下，于室温下在四氢呋喃中通过C-S键活化有效地进行，能够以中等至良好的产率和良好的官能团兼容性轻松组装各种结构多样的联芳基化合物。此外，还可以实现克级规模反应。
