Dunzendorfer U
Urol Int. 1985;40(5):241-50. doi: 10.1159/000281092.
The polyamine metabolism is pathologically changed in tumor tissues, and especially putrescine and spermidine demonstrate abnormally high values in kidney, bladder, and prostate cancer. The inductive processes which activate the biosynthetic polyamine enzymes in cancer are completely unknown. Of therapeutic interest is the fact that increased enzyme activities through irreversible inhibitors become significantly reduced, which consequently slows the tumor growth. Experimental therapy, especially in transplantable bladder and prostate cancer, displayed a 50% tumor destruction. In clinical studies using inhibitors of the polyamine biosynthesis, the dose had to be significantly reduced because of expressed toxicity. Additional investigations which tried a combination of reversible and irreversible inhibitors proved a similar antitumor activity, but less severe side effects.
肿瘤组织中的多胺代谢发生了病理改变，尤其是腐胺和亚精胺在肾癌、膀胱癌和前列腺癌中显示出异常高的值。激活癌症中生物合成多胺酶的诱导过程完全未知。具有治疗意义的是，通过不可逆抑制剂增加的酶活性会显著降低，从而减缓肿瘤生长。实验性治疗，特别是在可移植的膀胱癌和前列腺癌中，显示出50%的肿瘤破坏率。在使用多胺生物合成抑制剂的临床研究中，由于明显的毒性，剂量不得不显著降低。尝试可逆和不可逆抑制剂联合使用的进一步研究证明了类似的抗肿瘤活性，但副作用较轻。
