Paulík S
Vet Med (Praha). 1985 Nov;30(11):659-68.
The saturation effect of a serum and colostrum immunoglobulin preparation on the humoral immunity system of calves was studied during the first days after birth. The positive effect of the preparations depended on the dose and on the immunity level acquired through colostrum. The serum immunoglobulin preparation was used at three doses (1.2 ml, 1.6 ml, 2.2 ml per kg live weight). In the calves suffering from hypogammaglobulinaemia, a significant saturation effect was recorded only at the dose of 2.2 ml per kg live weight. This dose represented an amount greater by up to 79% than the recommended maximum therapeutic dose. The administration of the recommended dose of the colostral immunoglobulin preparation (20 ml per calf) positively influenced the concentration of serum immunoglobulins in 26% of the test calves, but these suffered from hypogammaglobulinaemia. In none of the cases of calves with a normal level of gammaglobulins and calves with diarrhoea was an increase in the concentration of serum immunoglobulins recorded. An increase in the concentration of serum immunoglobulins in the calves after the administration of the above mentioned preparations was so small that it appears impossible to use them in the saturation therapy in calves affected by hypogammaglobulinaemia and agammaglobulinaemia. Some of the mechanisms of the action of gammaglobulin preparations are discussed for the cases where the results of the administration of the preparations were positive.
在出生后的头几天，研究了血清和初乳免疫球蛋白制剂对犊牛体液免疫系统的饱和效应。这些制剂的积极作用取决于剂量以及通过初乳获得的免疫水平。血清免疫球蛋白制剂使用了三种剂量（每千克活重1.2毫升、1.6毫升、2.2毫升）。在患有低丙种球蛋白血症的犊牛中，仅在每千克活重2.2毫升的剂量下记录到显著的饱和效应。该剂量比推荐的最大治疗剂量高出多达79%。给予推荐剂量的初乳免疫球蛋白制剂（每头犊牛20毫升）对26%的受试犊牛血清免疫球蛋白浓度产生了积极影响，但这些犊牛患有低丙种球蛋白血症。在丙种球蛋白水平正常的犊牛和患有腹泻的犊牛中，均未记录到血清免疫球蛋白浓度的增加。给予上述制剂后，犊牛血清免疫球蛋白浓度的增加非常小，以至于似乎无法将它们用于患有低丙种球蛋白血症和无丙种球蛋白血症的犊牛的饱和治疗。针对制剂给药结果为阳性的情况，讨论了丙种球蛋白制剂的一些作用机制。
