Graduate Program in Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A. .
Department of Hepatology, Liver Institute Northwest, Seattle, WA, USA. .
J Gastrointestin Liver Dis. 2024 Sep 29;33(3):309-315. doi: 10.15403/jgld-5409.
Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory condition. Associated pathologies for EoE are similar to those with metabolic-dysfunction-associated steatotic liver disease (MASLD). This study assesses whether an association exists between MASLD and EoE.
We used National Inpatient Sample (NIS) 2020 data to identify adult patients. ICD-10 codes were used to identify patients with MASLD and EoE. The relationship between MASLD and EoE was assessed by multivariate analysis after adjusting for confounding factors, such as patient demographics, hospital characteristics, Charlson comorbidity index, obesity, obstructive sleep apnea (OSA), diabetes, hypertension (HTN), hyperlipidemia (HLD), inflammatory bowel disease (IBD), celiac disease (CD), gastroesophageal reflux disease (GERD), smoking, alcohol use, and irritable bowel syndrome (IBS).
Out of 26 million patients, 4,820 had a diagnosis of EoE. The majority of the patients were between 18 and 44 years of age (47.82%), male (54.05%), had private insurance (50.1%), and were in the highest income quartile (29.25%). A higher incidence of MASLD was noted in the EoE group than those without (6.1% vs.2.9%, p<0.001). After adjusting for confounding factors, MASLD had 2.38 times higher odds of having EoE (95% CI-1.82-3.11, p<0.001). Other factors noted to be associated with higher odds of EoE included younger age, Caucasian race, IBS, GERD, IBD, and CD.
Our study reports a novel finding that MASLD and EoE are associated. Future prospective studies are needed to confirm and understand the clinical significance of this relationship and how one disease affects the other.
嗜酸性食管炎（EoE）是一种慢性免疫介导的炎症性疾病。与 EoE 相关的病理学与代谢功能障碍相关的脂肪性肝病（MASLD）相似。本研究评估了 MASLD 与 EoE 之间是否存在关联。
我们使用国家住院患者样本（NIS）2020 年的数据来确定成年患者。使用 ICD-10 代码来识别 MASLD 和 EoE 患者。在调整混杂因素（如患者人口统计学、医院特征、Charlson 合并症指数、肥胖、阻塞性睡眠呼吸暂停（OSA）、糖尿病、高血压（HTN）、高脂血症（HLD）、炎症性肠病（IBD）、乳糜泻（CD）、胃食管反流病（GERD）、吸烟、饮酒和肠易激综合征（IBS））后，通过多变量分析评估 MASLD 与 EoE 之间的关系。
在 2600 万名患者中，有 4820 名患者被诊断为 EoE。大多数患者年龄在 18 至 44 岁之间（47.82%），男性（54.05%），拥有私人保险（50.1%），并且处于收入最高的四分位数（29.25%）。EoE 组的 MASLD 发生率明显高于无 EoE 组（6.1%比 2.9%，p<0.001）。在调整混杂因素后，MASLD 发生 EoE 的几率高 2.38 倍（95%CI-1.82-3.11，p<0.001）。其他与 EoE 发生几率增加相关的因素包括年龄较小、白种人、IBS、GERD、IBD 和 CD。
本研究报告了一个新的发现，即 MASLD 和 EoE 之间存在关联。未来需要前瞻性研究来证实和理解这种关系的临床意义以及一种疾病如何影响另一种疾病。
