Naurath H J, Füsgen I
Z Gerontol. 1985 Sep-Oct;18(5):302-4.
About 20 per cent of our patients between sixty and eighty years suffer from maturity onset diabetes including many subjects with an insulin requiring form. Beside cases of secondary failure were those with increased insulin resistance. In order to improve low compliance, a clear therapy is desirable. Therefore a combination of sulfonylurea with insulin is suitable instead of a repeated insulin-delivery by day. This way of treatment is known since the late fifties and its application increases in the last years. These results suggest that a combination with glibenclamide leads to a decrease of insulin-requirement. This is true both for secondary failure and difficult insulin monotherapy. More than 80 per cent of those patients who needed a twice by day insulin injection now do with only one delivery. The course of daily blood sugar profile is clearly smoothed.
在我们60至80岁的患者中，约20%患有成年型糖尿病，其中包括许多需要胰岛素治疗的患者。除了继发性失效的病例外，还有胰岛素抵抗增加的患者。为了提高依从性差的问题，需要一种明确的治疗方法。因此，磺脲类药物与胰岛素联合使用是合适的，而不是每天重复注射胰岛素。这种治疗方法自50年代末就已为人所知，近年来其应用有所增加。这些结果表明，与格列本脲联合使用可降低胰岛素需求量。这对于继发性失效和难治性胰岛素单一疗法均适用。现在，超过80%需要每日注射两次胰岛素的患者只需注射一次。每日血糖曲线明显变得平稳。
