Department of Otolaryngology, University of Utah School of Medicine, Salt Lake City, UT.
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT.
Oral Oncol. 2024 Dec;159:107041. doi: 10.1016/j.oraloncology.2024.107041. Epub 2024 Sep 29.
In the United States, approximately 63,000 Americans develop head and neck cancer (HNC) annually. Our study aims were to investigate cardiovascular complications and risk factors for development of CVD among HNC survivors.
Utilizing the Utah Populations Database, a total of 1,901 HNC patients diagnosed and 7,796 birth year, sex, and birth state matched individuals from the general population were identified. Multivariate Cox proportional hazard models were used.
Within the first two years after cancer diagnosis, HNC survivors had a higher likelihood of developing cardiovascular disease (CVD). High Charleston Comorbidity Index (CCI) score at baseline (Hazard Ratio (HR) 1.67, 95 % 1.28-2.17), stage II and IV disease (HR 1.80, 95 % 1.29-2.51), age >=65 years old (HR 2.31, 95 % 1.85-2.88), chemotherapy (HR 1.47, 95 % 1.15-1.88) were associated with increased CVD risk.
Compared to the general population, HNC survivors were more likely to develop cardiovascular diseases, particularly if they had the following risk factors: older age, stage II or IV cancer, high baseline CCI score, and chemotherapy were risk factors for development of CVD.
在美国，每年约有 63000 名美国人患上头颈部癌症（HNC）。我们的研究旨在调查头颈部癌症幸存者的心血管并发症和心血管疾病（CVD）发展的危险因素。
利用犹他州人群数据库，共确定了 1901 名 HNC 患者和 7796 名出生年份、性别和出生州匹配的普通人群个体。使用多变量 Cox 比例风险模型。
在癌症诊断后的头两年内，HNC 幸存者发生心血管疾病（CVD）的可能性更高。基线时高Charleston 合并症指数（CCI）评分（风险比（HR）1.67，95%置信区间（CI）1.28-2.17）、II 期和 IV 期疾病（HR 1.80，95%CI 1.29-2.51）、年龄>=65 岁（HR 2.31，95%CI 1.85-2.88）、化疗（HR 1.47，95%CI 1.15-1.88）与 CVD 风险增加相关。
与普通人群相比，HNC 幸存者更有可能患上心血管疾病，特别是如果他们有以下危险因素：年龄较大、癌症处于 II 期或 IV 期、基线 CCI 评分较高、以及接受化疗。
