Sauer Andrew J, Sherrod Charles F, Gosch Kensey L, Arnold Suzanne V, Reaney Matthew, Zhong Yue, Lam Jenny, Wyrwich Kathleen W, Spertus John A
University of Missouri Kansas City's Healthcare Institute for Innovations in Quality and Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA.
University of Missouri Kansas City's Healthcare Institute for Innovations in Quality and Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA.
J Card Fail. 2025 May;31(5):813-820. doi: 10.1016/j.cardfail.2024.09.010. Epub 2024 Sep 28.
A primary goal of treating patients with obstructive hypertrophic cardiomyopathy (oHCM) is to improve their symptoms, function and quality of life. Although the psychometric properties of the 23-item Kansas City Cardiomyopathy Questionnaire (KCCQ-23) have been described in oHCM, they have not been assessed for the shorter 12-item version (KCCQ-12), which is used increasingly in clinical practice.
Using data from the EXPLORER-HCM trial, the psychometric properties of the KCCQ-12 were evaluated. The KCCQ-12 domain and summary scores had moderate correlations with the most relevant clinical (New York Heart Association class, exercise duration, peak oxygen consumption) and patient-reported measures (EQ-5D-5L visual analog scale, Work Productivity and Activity Impairment [WPAI] questionnaire, and Hypertrophic Cardiomyopathy Symptom Questionnaire [HCMSQ]). KCCQ-12 domain scores had strong internal consistency, and test-retest reliability, demonstrated significant and proportional changes with differing magnitudes of clinical change (assessed by the patients' global impressions of change and the patients' impressions of severity), and they demonstrated close equivalence to the KCCQ-23 scores.
The KCCQ-12 demonstrated good psychometric performance for patients with oHCM, comparable to that of the KCCQ-23, supporting its use in clinical practice to care for patients with oHCM.
治疗梗阻性肥厚型心肌病（oHCM）患者的主要目标是改善其症状、功能和生活质量。尽管23项堪萨斯城心肌病问卷（KCCQ - 23）的心理测量特性已在oHCM中有所描述，但尚未对临床实践中越来越常用的较短的12项版本（KCCQ - 12）进行评估。
利用EXPLORER - HCM试验的数据，对KCCQ - 12的心理测量特性进行了评估。KCCQ - 12领域和总分与最相关的临床指标（纽约心脏协会分级、运动持续时间、峰值耗氧量）以及患者报告的指标（EQ - 5D - 5L视觉模拟量表、工作效率和活动障碍[WPAI]问卷以及肥厚型心肌病症状问卷[HCMSQ]）具有中等相关性。KCCQ - 12领域得分具有很强的内部一致性和重测信度，随不同程度的临床变化（通过患者对变化的总体印象和患者对严重程度的印象评估）呈现显著且成比例的变化，并且与KCCQ - 23得分显示出高度等效性。
KCCQ - 12在oHCM患者中表现出良好的心理测量性能，与KCCQ - 23相当，支持其在临床实践中用于护理oHCM患者。
