Department of Neuropsychiatry, Keio University School of Medicine, Shinanomachi 35, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Department of Psychiatry, NHO Shimofusa Psychiatric Medical Center, Chiba, Japan.
Sci Rep. 2024 Sep 30;14(1):22620. doi: 10.1038/s41598-024-70834-4.
Insomnia is a major concern among stressed workers worldwide. Although stress generally has a detrimental effect on sleep quality, the impact of biological stress, especially the immunological stress response, on sleep quality is not yet fully understood. Stressed workers were recruited through a screening process using a Brief Job Stress Questionnaire. The participants were asked to complete various occupation-related questionnaires. Additionally, saliva samples were collected to assess interleukin-6 (IL-6) levels as an immunological stress response. Subsequently, they were asked to wear an Apple Watch to record their sleep pattern for one week. Their sleep architecture was estimated using a previously published and validated method. Finally, data from 73 participants were analyzed. Our multivariable analysis revealed that shorter durations of slow-wave sleep (non-rapid eye movement sleep stage 3) were significantly associated with elevated IL-6 levels (p = 0.005) and greater daytime sleepiness (p = 0.002) after controlling for total sleep time. Our finding that a higher immunological stress response is associated with poor sleep quality contributes to a better understanding of insomnia in stressed workers and emphasizes the importance of stress management in this population.
失眠是全球压力大的劳动者面临的一个主要问题。尽管压力通常会对睡眠质量产生不利影响，但生物压力，特别是免疫应激反应对睡眠质量的影响还不完全清楚。通过使用简短工作压力问卷，通过筛选过程招募了压力大的劳动者。要求参与者完成各种与职业相关的问卷。此外，收集唾液样本以评估白细胞介素 6 (IL-6) 水平作为免疫应激反应的指标。随后，要求他们佩戴苹果手表记录一周的睡眠模式。使用先前发表并经过验证的方法来估计他们的睡眠结构。最后，对 73 名参与者的数据进行了分析。我们的多变量分析显示，在控制总睡眠时间后，慢波睡眠时间（非快速眼动睡眠阶段 3）较短与 IL-6 水平升高（p=0.005）和白天嗜睡（p=0.002）显著相关。我们发现，较高的免疫应激反应与较差的睡眠质量相关，这有助于更好地理解压力大的劳动者的失眠问题，并强调了在该人群中进行压力管理的重要性。
