Barton Katherine, Yellowman R Dexter, Holm Tara, Beaulieu Forrest, Zuckerberg Gabriel, Gwal Kriti, Setty Bindu N, Janitz Emily, Hwang Misun
Department of Radiology, Oregon Health & Science University, Portland, OR, USA.
Department of Diagnostic Radiology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mail Code L340, Portland, OR, 97239, USA.
Pediatr Radiol. 2024 Dec;54(13):2143-2156. doi: 10.1007/s00247-024-06066-5. Epub 2024 Oct 1.
Literature examining possible deleterious effects of anesthesia exposure on the developing brain has increased substantially over the past 30 years. Initial concerning findings in animal models, both rodents and non-human primates, prompted increasingly thorough examinations in humans, including randomized controlled trials. This review will provide a concise overview of what we know about anesthesia and the developing brain: the background in animal studies, the most robust results we have in humans, and the work yet to be done. This is particularly relevant to a pediatric radiology audience because we have the unique opportunity to modify anesthesia exposure during imaging through innovation.
在过去30年里，探讨麻醉暴露对发育中大脑可能产生有害影响的文献大幅增加。啮齿动物和非人类灵长类动物模型中的初步相关发现促使人们对人类进行越来越全面的研究，包括随机对照试验。本综述将简要概述我们对麻醉与发育中大脑的了解：动物研究的背景、我们在人类研究中得到的最可靠结果以及有待开展的工作。这对儿科放射学领域的读者尤为重要，因为我们有独特的机会通过创新来改变成像过程中的麻醉暴露情况。
