孕29周前胎膜早破（PPROM）的早产儿三岁时的长期神经发育结局。
Long-term neurodevelopmental outcomes at three years in preterm infants born before 29 Weeks gestation following Preterm Premature Rupture of Membranes (PPROM).
作者信息
Bhullar Harkirat, Stritzke Amelie, Makarchuk Sue, Tang Selphee, Lodha Abhay
机构信息
Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Alberta Health Services, Calgary, AB, Canada.
出版信息
J Perinatol. 2025 Feb;45(2):180-185. doi: 10.1038/s41372-024-02134-8. Epub 2024 Sep 30.
OBJECTIVE
To determine the association between preterm premature rupture of membranes (PPROM) and neurodevelopmental impairment (NDI) at 3 years corrected age (CA) in infants born before 29 weeks of gestational age (GA).
DESIGN/METHODS: Infants born before 29 weeks GA between 2005 and 2017 were included. The primary outcome was a composite of death or NDI (full-scale intelligence quotient<85, cerebral palsy, vision or hearing impairment) at 3 years of CA. Infants were stratified by maternal PPROM status. Associations were explored using multivariate models.
RESULTS
Of 1231 participants, 481 were in the PPROM group, and 750 were in the No PPROM group. After adjusting for factors, the odds ratio of death or NDI for PPROM vs. No PPROM was 1.22 (95% Confidence Interval 0.93-1.59).
CONCLUSION
Our study suggests that PPROM was not associated with an increased risk of a composite outcome of death or NDI at 3 years CA.
目的
确定孕周小于29周出生的婴儿在3岁矫正年龄时，胎膜早破（PPROM）与神经发育障碍（NDI）之间的关联。
设计/方法：纳入2005年至2017年间孕周小于29周出生的婴儿。主要结局是矫正年龄3岁时死亡或神经发育障碍（全量表智商<85、脑性瘫痪、视力或听力障碍）的综合情况。婴儿按母亲胎膜早破状态分层。使用多变量模型探讨关联。
结果
1231名参与者中，481名在胎膜早破组，750名在无胎膜早破组。校正因素后，胎膜早破组与无胎膜早破组相比，死亡或神经发育障碍的比值比为1.22（95%置信区间0.93 - 1.59）。
结论
我们的研究表明，胎膜早破与矫正年龄3岁时死亡或神经发育障碍综合结局风险增加无关。
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