Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
New South Wales Poisons Information Centre, The Sydney Children's Hospitals Network, Westmead, Australia.
Clin Toxicol (Phila). 2024 Oct;62(10):615-624. doi: 10.1080/15563650.2024.2398119. Epub 2024 Oct 1.
Poisoning is a leading cause of morbidity and mortality that is increasing in many countries. Better data are needed to understand epidemiology and outcomes of poisoning. This work describes a new poisoning data linkage cohort in New South Wales, Australia (population approximately 8 million).
This is a longitudinal health record linkage, 2011-2020, including data from: ambulance call-outs, emergency department presentations, hospital admissions, death registrations, the poisons centre, and four tertiary toxicology units. Individuals with poisoning, venomous animal/plant exposures, or adverse drug reaction events were included.
There were 845,217 linkable events relating to 400,642 ambulance, 688,484 emergency department, 682,013 admission, 40,456 toxicology, and 11,879 death records. There were 572,841 people with events; the median age at the time of first event was 57 years, and 51.9% were female. Events leading to patient admission were most commonly adverse drug reactions ( = 511,263), intentional poisonings ( = 68,646), unintentional poisonings ( = 54,840) and animal/plant exposures ( = 11,092). Demographics varied by cause: intentional poisoning (median age 33 years, 61.7% female); unintentional poisoning/animals/plants (median age 43 years, 45% female); and adverse drug reactions (median age 70 years, 54% female). Adolescent females had highest rates of intentional poisoning, while unintentional poisoning had a bimodal distribution, highest in children <5 years old and males aged 20 to 50 years. Substance use disorders were documented comorbidities for 44% of intentional poisoning, 29% of unintentional poisoning, and 13% of adverse drug reaction-related admissions; mood disorders were documented for 54%, 17% and 10% of these admissions, respectively.
Poisonings and hospitalised adverse drug reactions are common in New South Wales, affecting approximately 8% of the population in 10 years. This linkage improves understanding of poisoning risks and outcomes in Australia.
This novel data linkage provides a unique opportunity to study poisoning across multiple settings for an individual over an extended period.
中毒是导致许多国家发病率和死亡率上升的主要原因。为了更好地了解中毒的流行病学和结局，需要更好的数据。本研究在澳大利亚新南威尔士州（人口约 800 万）描述了一个新的中毒数据链接队列。
这是一项 2011 年至 2020 年的纵向健康记录链接研究，包括来自以下方面的数据：救护车出动、急诊科就诊、住院、死亡登记、中毒中心和四个三级毒理学单位。包括中毒、有毒动物/植物暴露或药物不良反应事件的个体。
共关联到 845217 个事件，涉及 400642 次救护车出动、688484 次急诊科就诊、682013 次住院、40456 次毒理学和 11879 次死亡记录。有 572841 人发生了事件；首次发生事件时的中位年龄为 57 岁，51.9%为女性。导致患者住院的事件最常见的是药物不良反应（511263 例）、故意中毒（68646 例）、意外中毒（54840 例）和动物/植物暴露（11092 例）。不同病因的人群特征也有所不同：故意中毒（中位年龄 33 岁，61.7%为女性）；意外中毒/动物/植物（中位年龄 43 岁，45%为女性）；药物不良反应（中位年龄 70 岁，54%为女性）。青少年女性故意中毒率最高，而意外中毒呈双峰分布，5 岁以下儿童和 20 至 50 岁男性最高。药物使用障碍被记录为 44%的故意中毒、29%的意外中毒和 13%的药物不良反应相关住院的合并症；情绪障碍分别被记录为这些住院患者的 54%、17%和 10%。
在新南威尔士州，中毒和住院药物不良反应很常见，在 10 年内影响了大约 8%的人口。这种链接提高了我们对澳大利亚中毒风险和结局的认识。
这种新的数据链接为个体在多个环境中研究中毒提供了一个独特的机会，时间跨度较长。
