Orrego-Pereira Carmen, Machuca-Aguado Jesús, Sánchez-Bernal María Luisa, Rubio-Garrido Francisco Javier
Pathology Department, Virgen Macarena University Hospital, Seville, Spain.
Int J Surg Pathol. 2025 May;33(3):679-681. doi: 10.1177/10668969241283490. Epub 2024 Oct 1.
Pulmonary hyalinizing granuloma (PHG) is a rare, benign condition characterized by slow-growing pulmonary nodules, often mimicking malignant lesions radiologically. Its pathogenesis is unclear but is thought to result from an exaggerated immune response to persistent antigenic stimuli. This report presents a case of a 71-year-old male with PHG, incidentally detected during imaging for acute appendicitis. Diagnostic challenges arose due to the radiological resemblance to metastatic disease, and inadequate biopsy samples. Surgical resection revealed fibrocollagenous nodules with perivascular inflammatory infiltrates. Immunohistochemistry and special stains excluded malignancy and infection. The clinical course of PHG is typically benign, with surgery being the treatment of choice for solitary lesions. However, the current terminology may be misleading, as the lesions are not true granulomas but rather fibrosing lesions. Further research is needed to clarify the underlying pathophysiology and improve diagnostic accuracy.
肺透明变性肉芽肿（PHG）是一种罕见的良性疾病，其特征为生长缓慢的肺结节，在影像学上常类似恶性病变。其发病机制尚不清楚，但被认为是对持续抗原刺激的过度免疫反应所致。本报告介绍了一例71岁男性患有PHG的病例，该病例在急性阑尾炎影像学检查时偶然发现。由于在放射学上与转移性疾病相似，且活检样本不足，出现了诊断挑战。手术切除显示为纤维胶原性结节伴血管周围炎性浸润。免疫组织化学和特殊染色排除了恶性肿瘤和感染。PHG的临床过程通常是良性的，手术是孤立性病变的首选治疗方法。然而，目前的术语可能会产生误导，因为这些病变并非真正的肉芽肿，而是纤维化病变。需要进一步研究以阐明潜在的病理生理学并提高诊断准确性。
