Kermanshah Arya, Rubini Silva Ceschim Mariana, Montes de Oca Daniel, Wakim Gisele J
Anesthesiology, University of Miami Miller School of Medicine, Miami, USA.
Cureus. 2024 Aug 31;16(8):e68289. doi: 10.7759/cureus.68289. eCollection 2024 Aug.
Protamine sulfate is commonly used to reverse the anticoagulant effects of unfractionated heparin (UFH) during surgical procedures, but its administration can sometimes trigger severe adverse reactions, including life-threatening anaphylaxis. We present the case of a 77-year-old male undergoing carotid endarterectomy who developed profound hypotension and tachycardia following protamine infusion. Anaphylaxis was confirmed by elevated tryptase levels. This case emphasizes the importance of vigilant monitoring during protamine administration, particularly in high-risk patients, and highlights the need to consider alternative reversal strategies to enhance patient safety.
硫酸鱼精蛋白常用于在外科手术期间逆转普通肝素（UFH）的抗凝作用，但其给药有时会引发严重不良反应，包括危及生命的过敏反应。我们报告一例77岁男性在接受颈动脉内膜切除术时，输注鱼精蛋白后出现严重低血压和心动过速的病例。类胰蛋白酶水平升高证实了过敏反应。该病例强调了在输注鱼精蛋白期间进行密切监测的重要性，尤其是在高危患者中，并突出了考虑替代逆转策略以提高患者安全性的必要性。
