Kumar Upadhyay Amitabh, Prakash Aaditya, Kumar Abhishek, Jena Sanghamitra, Sinha Neetesh, Sharma Swati
Medical Oncology, Tata Main Hospital, Jamshedpur, IND.
Radiation Oncology, Tata Main Hospital, Jamshedpur, IND.
Cureus. 2024 Aug 31;16(8):e68286. doi: 10.7759/cureus.68286. eCollection 2024 Aug.
Dr. Sidney Farber (Farber) was a distinguished pediatric pathologist and widely recognized pioneer of modern chemotherapy. In 1948, his influential study showed that various anti-folates, particularly 4-aminopteroylglutamic acid, also known as aminopterin, induced transient disease control in kids who had acute undifferentiated leukemia. The findings laid the basis for developing and using additional chemotherapies, individually or in combination, for treating pediatric and adult cancers. Farber also introduced actinomycin D to treat Wilms tumor in various stages. Underneath his oversight, the 'Jimmy Fund,' one of the earliest dedicated pediatric oncology centers, and the Children's Cancer Research Foundation, which subsequently evolved into the Dana-Farber Cancer Institute, was established. Farber is known as the "Founder of Pediatric Pathology" and the "Father of Modern Chemotherapy," citing his immense contributions. This article is a tribute to the great scientist Farber for his significant contributions to the scientific field and the countless individuals he has impacted.
西德尼·法伯博士（法伯）是一位杰出的儿科病理学家，也是现代化疗广为人知的先驱。1948年，他的一项有影响力的研究表明，各种抗叶酸药物，特别是4-氨基蝶酰谷氨酸，也称为氨基蝶呤，能使患有急性未分化白血病的儿童实现短暂的病情控制。这些发现为开发和使用单独或联合的其他化疗方法来治疗儿童和成人癌症奠定了基础。法伯还引入放线菌素D来治疗各个阶段的肾母细胞瘤。在他的监督下，最早的专门儿科肿瘤中心之一“吉米基金”以及后来发展成为丹娜-法伯癌症研究所的儿童癌症研究基金会得以成立。鉴于法伯的巨大贡献，他被誉为“儿科病理学奠基人”和“现代化疗之父”。本文是对伟大科学家法伯的致敬，感谢他对科学领域的重大贡献以及他所影响的无数人。
