Razavi Peyman, Vingopoulos Filippos, Garcia Mauricio, Romano Francesco, Choi Hanna, Ding Xinyi, Garg Itika, Baldwin Grace, Zeng Rebecca, Finn Matthew, Bannerman Augustine, Wescott Hannah, Kim Leo A, Husain Deeba, Vavvas Demetrios, Miller John B
Harvard Retinal Imaging Lab, Boston, MA, USA.
Retina Service, Massachusetts Eye and Ear, Boston, MA, USA.
J Vitreoretin Dis. 2024 Jul 30;8(5):533-539. doi: 10.1177/24741264241259245. eCollection 2024 Sep-Oct.
To investigate whether there is visual function impairment in patients with posterior vitreous detachment (PVD) using the active-learning quantitative contrast sensitivity function test. In this cross-sectional study, contrast sensitivity was measured in eyes with PVD and eyes without PVD using the quantitative contrast sensitivity function algorithm on the Adaptive Sensory Technology platform. Outcomes included the area under the log contrast sensitivity function curve, contrast acuity, and contrast sensitivity thresholds at 1 to 18 cycles per degree (cpd). Snellen visual acuity (VA) was also measured. Mixed-effects multiple linear regression analyses were performed to evaluate the association between the presence of PVD and visual function, controlling for age and lens status. The cohort comprised 232 healthy eyes of 205 participants; of these, 80 eyes of 69 patients had PVD. There was no significant association between VA and PVD presence. However, PVD was significantly associated with decreased contrast sensitivity thresholds at 1.5 cpd (β, -0.058; = .003) and 3 cpd (β, -0.067; = .004). Contrast sensitivity thresholds at lower (1 cpd) or higher (6, 12, 18 cpd) spatial frequencies did not significantly correlate with PVD presence. Even in the subgroup of symptomatic PVD eyes, VA was not significantly decreased, while quantitative contrast sensitivity function outcomes showed visual function deficits at low spatial frequencies (1.5 cpd and 3 cpd). Contrast sensitivity measured with the quantitative contrast sensitivity function test showed visual function deficits in eyes with PVD that would have been missed with VA testing alone. Incorporating this test in the retina clinic might offer a more comprehensive functional assessment of eyes with PVD, serving as an adjunct outcome metric in clinical decision-making.
使用主动学习定量对比敏感度函数测试来研究玻璃体后脱离（PVD）患者是否存在视觉功能损害。在这项横断面研究中，使用自适应感官技术平台上的定量对比敏感度函数算法，对患有PVD的眼睛和未患有PVD的眼睛进行对比敏感度测量。结果包括对数对比敏感度函数曲线下的面积、对比视力以及每度1至18周/度（cpd）的对比敏感度阈值。还测量了Snellen视力（VA）。进行混合效应多元线性回归分析，以评估PVD的存在与视觉功能之间的关联，并控制年龄和晶状体状态。该队列包括205名参与者的232只健康眼睛；其中，69名患者的80只眼睛患有PVD。VA与PVD的存在之间没有显著关联。然而，PVD与1.5 cpd（β，-0.058；P = 0.003）和3 cpd（β，-0.067；P = 0.004）时对比敏感度阈值降低显著相关。较低（1 cpd）或较高（6、12、18 cpd）空间频率下的对比敏感度阈值与PVD的存在没有显著相关性。即使在有症状的PVD眼睛亚组中，VA也没有显著降低，而定量对比敏感度函数结果显示在低空间频率（1.5 cpd和3 cpd）存在视觉功能缺陷。通过定量对比敏感度函数测试测量的对比敏感度显示，PVD眼睛存在视觉功能缺陷，而仅通过VA测试会遗漏这些缺陷。在视网膜诊所采用这项测试可能会对PVD眼睛提供更全面的功能评估，作为临床决策中的辅助结果指标。
