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直接靶向生热脂肪组织中的 PRDM16 以治疗肥胖及其相关代谢疾病。

Directly targeting PRDM16 in thermogenic adipose tissue to treat obesity and its related metabolic diseases.

机构信息

The First Affiliated Hospital, Guangdong Pharmaceutical University, Guangzhou, China.

School of Basic Medicine, Hubei University of Arts and Science, Xiangyang, China.

出版信息

Front Endocrinol (Lausanne). 2024 Sep 16;15:1458848. doi: 10.3389/fendo.2024.1458848. eCollection 2024.

DOI:10.3389/fendo.2024.1458848
PMID:39351529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11439700/
Abstract

Obesity is increasing globally and is closely associated with a range of metabolic disorders, including metabolic associated fatty liver disease, diabetes, and cardiovascular diseases. An effective strategy to combat obesity involves stimulating brown and beige adipocyte thermogenesis, which significantly enhances energy expenditure. Recent research has underscored the vital role of PRDM16 in the development and functionality of thermogenic adipocytes. Consequently, PRDM16 has been identified as a potential therapeutic target for obesity and its related metabolic disorders. This review comprehensively examines various studies that focus on combating obesity by directly targeting PRDM16 in adipose tissue.

摘要

肥胖症在全球范围内不断增加，与一系列代谢紊乱密切相关，包括代谢相关脂肪性肝病、糖尿病和心血管疾病。对抗肥胖的有效策略包括刺激棕色和米色脂肪细胞产热，这可显著增加能量消耗。最近的研究强调了 PRDM16 在产热脂肪细胞的发育和功能中的重要作用。因此，PRDM16 已被确定为肥胖及其相关代谢紊乱的潜在治疗靶点。本综述全面考察了通过直接靶向脂肪组织中的 PRDM16 来对抗肥胖的各种研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/593d/11439700/362b3dc004af/fendo-15-1458848-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/593d/11439700/4a72af1ad732/fendo-15-1458848-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/593d/11439700/c8b6bfd5e60e/fendo-15-1458848-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/593d/11439700/362b3dc004af/fendo-15-1458848-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/593d/11439700/4a72af1ad732/fendo-15-1458848-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/593d/11439700/c8b6bfd5e60e/fendo-15-1458848-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/593d/11439700/362b3dc004af/fendo-15-1458848-g003.jpg

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