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通过整合基因组不稳定性和长链非编码RNA特征推进肝细胞癌的预后理解：GILncSig模型

Advancing prognostic understanding in hepatocellular carcinoma through the integration of genomic instability and lncRNA signatures: GILncSig model.

作者信息

Bocchetti Marco, Misso Gabriella, Zappavigna Silvia, Scrima Marianna, Caraglia Michele, Pentimalli Francesca, Cossu Alessia Maria

机构信息

Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples 80138, Italy.

Department of Molecular and Precision Oncology, Biogem Scarl, Institute of Genetic Research, Ariano Irpino 83031, Italy.

出版信息

World J Gastrointest Surg. 2024 Sep 27;16(9):2774-2777. doi: 10.4240/wjgs.v16.i9.2774.

DOI:10.4240/wjgs.v16.i9.2774
PMID:39351545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11438822/
Abstract

The recently published study by Duan introduces a promising method that combines genomic instability and long non-coding RNAs to improve the prognostic evaluation of hepatocellular carcinoma (HCC), a deadly cancer associated with considerable morbidity and mortality. This editorial aims to analyze the methodology, key findings, and broader implications of the study within the fields of gastroenterology and oncological surgery, highlighting the shift towards precision medicine in the management of HCC.

摘要

段最近发表的研究介绍了一种很有前景的方法，该方法结合了基因组不稳定性和长链非编码RNA，以改善肝细胞癌（HCC）的预后评估，HCC是一种与相当高的发病率和死亡率相关的致命癌症。这篇社论旨在分析该研究在胃肠病学和肿瘤外科领域的方法、主要发现及更广泛的意义，强调在HCC管理中向精准医学的转变。

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本文引用的文献

1
Construction and validation of somatic mutation-derived long non-coding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma.构建和验证基于体细胞突变的基因组不稳定性长链非编码RNA特征以预测肝细胞癌预后
World J Gastrointest Surg. 2024 Mar 27;16(3):842-859. doi: 10.4240/wjgs.v16.i3.842.
2
A New Understanding of Long Non-Coding RNA in Hepatocellular Carcinoma-From mA Modification to Blood Biomarkers.长链非编码 RNA 在肝细胞癌中的新认识——从 mA 修饰到血液生物标志物。
Cells. 2023 Sep 14;12(18):2272. doi: 10.3390/cells12182272.
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A Ferroptosis-Related LncRNA Signature Associated with Prognosis, Tumor Immune Environment, and Genome Instability in Hepatocellular Carcinoma.一个与肝细胞癌预后、肿瘤免疫微环境和基因组不稳定性相关的铁死亡相关长非编码 RNA 特征。
Comput Math Methods Med. 2022 Aug 18;2022:6284540. doi: 10.1155/2022/6284540. eCollection 2022.
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Construction of a Novel LncRNA Signature Related to Genomic Instability to Predict the Prognosis and Immune Activity of Patients With Hepatocellular Carcinoma.构建与基因组不稳定性相关的新型长链非编码 RNA 标志物，预测肝细胞癌患者的预后和免疫活性。
Front Immunol. 2022 Apr 8;13:856186. doi: 10.3389/fimmu.2022.856186. eCollection 2022.
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Development and Validation of Genome Instability-Associated lncRNAs to Predict Prognosis and Immunotherapy of Patients With Hepatocellular Carcinoma.用于预测肝细胞癌患者预后和免疫治疗的基因组不稳定性相关长链非编码RNA的开发与验证
Front Genet. 2022 Jan 28;12:763281. doi: 10.3389/fgene.2021.763281. eCollection 2021.
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Genomic Instability of Mutation-Derived Gene Prognostic Signatures for Hepatocellular Carcinoma.肝细胞癌突变衍生基因预后特征的基因组不稳定性
Front Cell Dev Biol. 2021 Oct 5;9:728574. doi: 10.3389/fcell.2021.728574. eCollection 2021.
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