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胰十二指肠切除术后胃空肠吻合口漏的内镜下夹闭术:一例报告

Endoscopic clipping of gastrojejunostomy leakage following Whipple procedure: A case report.

作者信息

Muhammedoğlu Bahtiyar, Ay Oguzhan Fatih

机构信息

Department of General Surgery, Kahramanmaras Sutcu İmam University Medical Faculty, Kahramanmaras 46040, Türkiye.

Department of General Surgery, Kahramanmaras Necip Fazıl City Hospital, Kahramanmaras 46140, Türkiye.

出版信息

World J Gastrointest Surg. 2024 Sep 27;16(9):3041-3047. doi: 10.4240/wjgs.v16.i9.3041.

DOI:10.4240/wjgs.v16.i9.3041
PMID:39351554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11438800/
Abstract

BACKGROUND

Currently, perioperative complications of classic Whipple surgery occur at a rate of approximately 40%. Common complications include delayed gastric emptying, pancreatic fistula, and bile leakage, whereas gastrojejunostomy (GJ) leakage is rare.

CASE SUMMARY

This case report will assess the management of a GJ leak in a 71-year-old male patient following the Whipple procedure. After surgery, the patient was transferred to the clinic after four days of intensive care, where vacuum therapy was used to handle a developing subcutaneous collection. The patient, who had bile in the drains and incision during follow-up, underwent endoscopic examination on the 21 day after the operation. An opening of approximately 4 mm was observed in the GJ anastomosis during endoscopy. Five titanium clips were used to close the openings. The drainage of bile decreased to less than 50 mL on the first day after the procedure, and the patient's oral intake was opened.

CONCLUSION

Current literature reports a GJ leakage rate of 0. 54% following Whipple surgery, with clinical findings lasting on average between 4-34 days. Surgery was the main form of therapy for this case, with a success rate of 84%, and percutaneous drainage was also utilized as a treatment option. This case report is the first to document endoscopic treatment of GJ leaks following the classic Whipple procedure.

摘要

背景

目前,经典惠普尔手术的围手术期并发症发生率约为40%。常见并发症包括胃排空延迟、胰瘘和胆漏,而胃空肠吻合口(GJ)漏则较为罕见。

病例摘要

本病例报告将评估一名71岁男性患者在惠普尔手术后发生GJ漏的处理情况。术后,患者在重症监护4天后转至门诊,采用负压疗法处理逐渐形成的皮下积液。随访期间引流管及切口有胆汁引出的患者,在术后第21天行内镜检查。内镜检查发现GJ吻合口有一约4mm的开口。使用5个钛夹封闭开口。术后第一天胆汁引流量减少至50mL以下,患者开始经口进食。

结论

目前文献报道惠普尔手术后GJ漏发生率为0.54%,临床表现平均持续4 - 34天。手术是该病例的主要治疗方式,成功率为84%,经皮引流也作为一种治疗选择。本病例报告首次记录了经典惠普尔手术后GJ漏的内镜治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc4/11438800/f6cc86a52f2a/WJGS-16-3041-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc4/11438800/6c416546c047/WJGS-16-3041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc4/11438800/fc25a2c593b0/WJGS-16-3041-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc4/11438800/cde240b43fd9/WJGS-16-3041-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc4/11438800/24a33f0730e2/WJGS-16-3041-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc4/11438800/f6cc86a52f2a/WJGS-16-3041-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc4/11438800/6c416546c047/WJGS-16-3041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc4/11438800/fc25a2c593b0/WJGS-16-3041-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc4/11438800/cde240b43fd9/WJGS-16-3041-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc4/11438800/24a33f0730e2/WJGS-16-3041-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc4/11438800/f6cc86a52f2a/WJGS-16-3041-g005.jpg

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本文引用的文献

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From Classic Whipple to Pylorus Preserving Pancreaticoduodenectomy and Ultimately to Pylorus Resecting - Stomach Preserving Pancreaticoduodenectomy: A Review.从经典的胰十二指肠切除术(Whipple 手术)到保留幽门的胰十二指肠切除术,再到最终的保留胃的胰十二指肠切除术:综述。
Chirurgia (Bucur). 2023 Aug;118(4):335-347. doi: 10.21614/chirurgia.2023.v.118.i.4.p.335.
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Treatment and Prevention of Postoperative Leakage after Gastrectomy for Gastric Cancer.胃癌胃切除术后吻合口漏的治疗与预防
J Clin Med. 2023 Jun 6;12(12):3880. doi: 10.3390/jcm12123880.
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Gastro- or Duodenojejunostomy Leaks After Pancreatoduodenectomy: Single Center Experience and Narrative Literature Review.
胰十二指肠切除术后胃或十二指肠空肠吻合口漏:单中心经验和叙事文献复习。
J Gastrointest Surg. 2021 Dec;25(12):3130-3136. doi: 10.1007/s11605-021-05058-2. Epub 2021 Jun 15.
4
Computed tomography evaluation of early post-operative complications of the Whipple procedure.胰十二指肠切除术术后早期并发症的计算机断层扫描评估
Pol J Radiol. 2020 Feb 19;85:e104-e109. doi: 10.5114/pjr.2020.93399. eCollection 2020.
5
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J Pancreat Cancer. 2020 Feb 6;6(1):5-11. doi: 10.1089/pancan.2019.0016. eCollection 2020.
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