Department of Obstetrics and Gynaecology, University of Campinas (UNICAMP), Faculty of Medical Sciences, Campinas, SP, Brazil.
Eur J Contracept Reprod Health Care. 2024 Dec;29(6):282-286. doi: 10.1080/13625187.2024.2406496. Epub 2024 Oct 1.
To evaluate improvements in laboratory markers of anaemia (haemoglobin, haematocrit, serum iron, and ferritin) in women with subjective heavy menstrual bleeding (HMB) treated with the levonorgestrel 19.5-mg intrauterine device.
We conducted a pilot study at the Department of Obstetrics and Gynaecology, University of Campinas, Faculty of Medical Sciences, Campinas, SP, Brazil. We compared anaemia markers in 73 women aged 18-48 years suffering from HMB, one year after placement of the IUD.
The mean age of participants was 30.0 years (range 24-38); more than half were white, and the mean body mass index (kg/m) was 27.0. Twenty (27.4%) participants exited the study due to loss to follow-up ( = 12; 16.4%), expulsion ( = 7; 9.6%) and uterine perforation ( = 1; 1.4%). One-year post-IUD placement, amenorrhoea was reported by 10 (13.7%) women. According to intention-to-treat and per protocol analyses, the proportion of women with normal haemoglobin levels significantly improved ( = 0.014 in both analyses), as did haematocrit ( < 0.001 in both analyses) and serum iron ( = 0.003 in both analyses) compared to baseline evaluations. The proportion of women with normal ferritin levels also improved ( < 0.001) in both analyses using a cut-off of 15 ng/ml, though no significant difference was observed using a 30 ng/ml cut-off ( = 0.083 in both analyses).
The levonorgestrel 19.5-mg IUD effectively improved laboratory markers of anaemia one year after placement in women with HMB.
评估左炔诺孕酮 19.5 毫克宫内节育器治疗有主观月经过多（HMB）的女性的贫血实验室指标（血红蛋白、血细胞比容、血清铁和铁蛋白）的改善情况。
我们在巴西坎皮纳斯大学医学科学系妇产科进行了一项试点研究。我们比较了 73 名年龄在 18-48 岁的 HMB 女性在放置宫内节育器一年后的贫血标志物。
参与者的平均年龄为 30.0 岁（范围 24-38）；超过一半为白人，平均体重指数（kg/m）为 27.0。由于失访（ = 12；16.4%）、脱落（ = 7；9.6%）和子宫穿孔（ = 1；1.4%），有 20 名（27.4%）参与者退出了研究。放置宫内节育器一年后，有 10 名（13.7%）女性出现闭经。根据意向治疗和方案分析，血红蛋白水平正常的女性比例显著提高（ = 0.014 在两种分析中），血细胞比容（ < 0.001 在两种分析中）和血清铁（ = 0.003 在两种分析中）与基线评估相比也有所改善。在两种分析中，使用 15ng/ml 的截定点，铁蛋白水平正常的女性比例也有所提高（ < 0.001），但使用 30ng/ml 的截定点时则没有观察到显著差异（ = 0.083 在两种分析中）。
左炔诺孕酮 19.5 毫克宫内节育器在放置 HMB 女性一年后有效改善了贫血的实验室指标。
