Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Neurol Res. 2024 Dec;46(12):1181-1190. doi: 10.1080/01616412.2024.2407645. Epub 2024 Oct 1.
Patients who have Parkinson's disease (PD) present several non-motor issues, such as sexual dysfunction. Deep brain stimulation (DBS) is a great treatment for PD and could affect both motor and non-motor symptoms of patients.
The main goal of the current study is to evaluate the impact of DBS on the sexual dysfunction among patients with PD.
Five databases (PubMed, Scopus, Embase, Web of Science, and Cochrane Library) were searched for records. Studies that measured the effect of DBS sexual function were included. The risk of bias assessment tool of non-randomized studies of interventions (ROBINS-I) was used to assess the quality of the included studies. The before and after data extraction and statistical analysis were performed using the Comprehensive Meta-analysis software (CMA) version 3.0.
Ten studies were included in the systematic review; six of them were eligible to perform a meta-analysis with a total sample size of 532 participants and a mean age of 62.21 ± 1.59 years. All participants performed STN-DBS. The sexual function of participants after STN-DBS implantation significantly increased (SMD = -0.124, 95% CI: -0.209 to -0.038, -value = 0.005). It also did not have any publication bias. Additionally, their quality of life mounts significantly (SMD = -0.712, 95% CI: -1.002 to -0.422, -value <0.001).
Our systematic review highlights the potential effect of STN-DBS on reducing the sexual dysfunction of patients with PD and boosting their quality of life.
帕金森病（PD）患者存在多种非运动问题，如性功能障碍。脑深部电刺激（DBS）是 PD 的一种重要治疗方法，可能会影响患者的运动和非运动症状。
本研究的主要目的是评估 DBS 对 PD 患者性功能障碍的影响。
检索了 5 个数据库（PubMed、Scopus、Embase、Web of Science 和 Cochrane Library）以获取记录。纳入了测量 DBS 对性功能影响的研究。使用非随机干预研究的偏倚风险评估工具（ROBINS-I）评估纳入研究的质量。使用 Comprehensive Meta-analysis 软件（CMA）版本 3.0 进行数据提取和统计分析。
系统评价纳入了 10 项研究；其中 6 项研究符合进行荟萃分析的条件，共纳入 532 名参与者，平均年龄为 62.21±1.59 岁。所有参与者均进行了 STN-DBS。STN-DBS 植入后，参与者的性功能明显提高（SMD=-0.124，95%CI：-0.209 至 -0.038，-值=0.005）。并且不存在发表偏倚。此外，他们的生活质量也显著提高（SMD=-0.712，95%CI：-1.002 至 -0.422，-值<0.001）。
本系统评价强调了 STN-DBS 降低 PD 患者性功能障碍和提高生活质量的潜在作用。
