Vrignaud P, Denechaud M
Bull Cancer. 1985;72(3):227-32.
In order to understand the kinetics of this experimental model, we studied the influence of age and sex on primary tumoral and pulmonary metastatic yields and on the growth kinetics parameters. Connective tissue tumors were induced by DMBA in male and female Swiss mice of various ages (pre and postpubertal, adult and menopausal). Old mice (induced during the post-menopausal period) show the lowest yield and the slowest growth kinetics. However, prepubertal mice show the highest yield and rapid tumor growth. The characteristics of this experimental model, and particularly the different responsiveness with age, suggest that it may be of value in human preclinical studies.
为了了解该实验模型的动力学，我们研究了年龄和性别对原发性肿瘤及肺转移率以及生长动力学参数的影响。用二甲基苯蒽（DMBA）诱导不同年龄（青春期前、青春期后、成年和绝经后）的雄性和雌性瑞士小鼠产生结缔组织肿瘤。老年小鼠（在绝经后时期诱导）的肿瘤发生率最低，生长动力学最慢。然而，青春期前小鼠的肿瘤发生率最高，肿瘤生长迅速。该实验模型的特点，尤其是随年龄变化的不同反应性，表明它在人类临床前研究中可能具有价值。
