Chen Mu-Hong, Tsai Shih-Jen, Cheng Chih-Ming, Chang Wen-Han, Bai Ya-Mei, Su Tung-Ping, Chen Tzeng-Ji
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Mayo Clin Proc. 2024 Sep 6. doi: 10.1016/j.mayocp.2024.06.014.
To investigate the risks of suicide, accidental death, and major psychiatric disorders in first-degree relatives (FDRs) of people who die accidentally. Evidence has shown that the endophenotypes of impulsivity and risk-taking are known to coaggregate with major psychiatric disorders, suicide, and accidental deaths within families.
In total, 136,011 FDRs of individuals who died from accidents and 544,044 individuals matched for age and sex who served as a control group were included in the present study. The relative risks of accidental death and suicide were assessed between these groups. Differences in the frequencies of major psychiatric disorders, including schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder, and attention deficit hyperactivity disorder (ADHD) between the groups were also identified.
The FDRs of individuals who died from accidents were more likely to themselves die from accidents (relative risk [RR] = 4.62) and by suicide (RR = 1.54) compared with individuals in the control group. The FDRs of individuals who died from accidents had an increased risk of developing schizophrenia (RR = 1.24), bipolar disorder (RR = 1.18), major depressive disorder (RR = 1.26), and attention deficit hyperactivity disorder (RR = 1.10) compared with the FDRs of individuals who did not die from accidents.
Our findings may serve as a reminder to public health officials and clinicians to monitor closely the mental health of the FDRs of individuals who die from accidents.
调查意外死亡者的一级亲属（FDRs）自杀、意外死亡及患重大精神障碍的风险。有证据表明，冲动性和冒险行为的内表型在家族中与重大精神障碍、自杀及意外死亡共同聚集。
本研究纳入了136,011名意外死亡者的FDRs以及544,044名年龄和性别匹配的个体作为对照组。评估了两组之间意外死亡和自杀的相对风险。还确定了两组之间包括精神分裂症、双相情感障碍、重度抑郁症、自闭症谱系障碍和注意力缺陷多动障碍（ADHD）在内的重大精神障碍发生率的差异。
与对照组个体相比，意外死亡者的FDRs自身死于意外（相对风险[RR]=4.62）和自杀（RR=1.54）的可能性更高。与未意外死亡者的FDRs相比，意外死亡者的FDRs患精神分裂症（RR=1.24）、双相情感障碍（RR=1.18）、重度抑郁症（RR=1.26）和注意力缺陷多动障碍（RR=1.10）的风险增加。
我们的研究结果可能提醒公共卫生官员和临床医生密切监测意外死亡者FDRs的心理健康。
