Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Department of Clinical Oncology, Tuen Mun Hospital, Hospital Authority, Tuen Mun, Hong Kong.
Support Care Cancer. 2024 Oct 1;32(10):695. doi: 10.1007/s00520-024-08864-x.
Ductal carcinoma in situ (DCIS) of the breast is one of the most common pre-invasive cancers diagnosed in women. Quality of life (QoL) is extremely important to assess in studies including these patients due to the favorable prognosis of the disease. The primary objective of this systematic review was to compile a comprehensive list of QoL issues, all existing QoL assessment tools, and patient-reported outcome measures used to assess DCIS.
A search was conducted on Ovid MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases from inception to August 2023, using keywords such as "ductal carcinoma in-situ", "quality of life", and "patient-reported outcomes." QoL issues and QoL tools in primary research studies were extracted.
A total of 67 articles identified issues pertaining to patients with DCIS spanning physical, functional, and psychosocial QoL domains. Physical and functional issues observed in patients included pain, fatigue, and impaired sexual functioning. Psychosocial issues such as anxiety, depression, and confusion about one's disease were also common. QoL tools included those that assessed general QoL, breast cancer-specific tools, and issue-specific questionnaires.
The current instruments available to assess QoL in patients with DCIS do not comprehensively capture the issues that are pertinent to patients. Thus, the modification of existing tools or the creation of a DCIS-specific QoL tool is recommended to ensure that future research will be sensitive towards challenges faced by patients with DCIS.
乳腺导管原位癌（DCIS）是女性最常见的一种前浸润性癌。由于该疾病的预后良好，在包括这些患者的研究中，评估生活质量（QoL）极其重要。本系统评价的主要目的是综合列出与 DCIS 相关的 QoL 问题、所有现有的 QoL 评估工具以及用于评估 DCIS 的患者报告结局测量。
从 Ovid MEDLINE、EMBASE 和 Cochrane 对照试验中心注册数据库中检索从开始到 2023 年 8 月的文献，使用的关键词包括“导管原位癌”、“生活质量”和“患者报告的结果”。从原始研究中提取与 DCIS 患者相关的 QoL 问题和 QoL 工具。
共确定了 67 篇文章，这些文章涵盖了患者的身体、功能和社会心理 QoL 领域的问题。患者中观察到的身体和功能问题包括疼痛、疲劳和性功能障碍。焦虑、抑郁和对疾病的困惑等心理社会问题也很常见。QoL 工具包括评估一般 QoL 的工具、乳腺癌专用工具和特定问题的问卷。
目前用于评估 DCIS 患者 QoL 的工具不能全面捕捉与患者相关的问题。因此，建议修改现有的工具或创建 DCIS 特异性 QoL 工具，以确保未来的研究能够敏感地关注 DCIS 患者面临的挑战。
