Department of Pharmacy, Hospital de Galdakao-Usansolo, Barrio Labeaga 46A, Galdakao, 48960, Spain.
Research Unit, Hospital de Galdakao-Usansolo, Galdakao, Spain.
J Patient Rep Outcomes. 2024 Oct 1;8(1):116. doi: 10.1186/s41687-024-00780-2.
The aim of this study was to determine the psychometric properties of the Spanish-language version of the HIV-Symptom Index (HIV-SI) questionnaire in Spanish patients undergoing antiretroviral therapy.
Between 2014 and 2016, an observational, multicenter, prospective cohort study was conducted in seventeen Spanish hospitals to validate HIV-SI questionnaire in terms of: construct validity (confirmatory factor analysis), internal consistency (Cronbach's alpha), convergent validity (Pearson's correlation coefficient) and Known-group validity. In addition, a sensitivity to change analysis was also performed.
A total of 232 patients were included in the study. They had a mean age of 46.17 (SD9.82) and were 75% male. The median overall score for the HIV-SI was 10 (IQR 4- 19.5) and the most common symptoms reported were feelings of nervousness or anxiety, fatigue or energy loss, feeling sad or depressed, stomach pain or bloating, and difficulty sleeping. In the current study, the Spanish HIV-SI questionnaire showed a high internal consistency (α = 0.89) and adequate construct validity (CFI and TLI > 0.90). When contrasted with the MOS-HIV questionnaire, an inverse correlation was found. It showed a good association with the mental (r=-0.61; P < 0.0001) and physical score (r=-0.60; P < 0.0001). In a multivariate analysis, the age of the patient, female condition, hepatitis C coinfection, concomitant treatment and non-adherence resulted in a higher HIV-SI score.
Our study has shown that the Spanish HIV-SI is a valid and reliable self-administered PROM for routine measurement of patient- reported symptoms among Spanish patients on antiretroviral treatment.
本研究旨在确定接受抗逆转录病毒治疗的西班牙语患者的 HIV 症状指数（HIV-SI）问卷的西班牙语版本的心理测量特性。
在 2014 年至 2016 年期间，在十七家西班牙医院进行了一项观察性、多中心、前瞻性队列研究，以验证 HIV-SI 问卷在以下方面的有效性：结构有效性（验证性因子分析）、内部一致性（Cronbach's alpha）、收敛有效性（Pearson 相关系数）和已知组有效性。此外，还进行了敏感性分析。
共有 232 名患者纳入研究。他们的平均年龄为 46.17（SD9.82）岁，75%为男性。HIV-SI 的总中位数评分为 10（IQR 4-19.5），报告的最常见症状为紧张或焦虑感、疲劳或能量损失、悲伤或抑郁感、胃痛或腹胀以及睡眠困难。在本研究中，西班牙 HIV-SI 问卷表现出较高的内部一致性（α=0.89）和良好的结构有效性（CFI 和 TLI>0.90）。与 MOS-HIV 问卷相比，发现了一种反向相关性。它与精神（r=-0.61；P<0.0001）和身体评分（r=-0.60；P<0.0001）具有良好的相关性。在多变量分析中，患者的年龄、女性状况、丙型肝炎合并感染、伴随治疗和不依从性导致 HIV-SI 评分更高。
我们的研究表明，西班牙语 HIV-SI 是一种有效的、可靠的自我管理 PROM，可用于常规测量接受抗逆转录病毒治疗的西班牙患者的报告症状。
