Ibarra-Barrueta Olatz, Mora-Atorrasagasti Oihana, Legarreta María José, Illaro-Uranga Aitziber, Morillo-Verdugo Ramón
Servicio de Farmacia, Hospital de Urdúliz-Alfredo Espinosa, Urdúliz.
Servicio de Farmacia. Hospital Galdakao-Usansolo, Galdakao.
Farm Hosp. 2019 May 1;43(3):87-93. doi: 10.7399/fh.11127.
The primary endpoint is to validate the HIV Symptoms Index Questionnaire in a Spanish population, in terms of comprehension and acceptability. The secondary endpoints are to describe symptoms reported by patients, tolerance, and quality of life.
The pilot trial of an observational and multicenter non-comparative study, for the validation of the HIV Symptoms Index Questionnaire in a Spanish population. Patients over the age of 18 diagnosed with HIV infection and receiving treatment were included. The symptoms index, treatment adherence based on pharmacy dispensing records, and quality of life with MOS-HIV questionnaire were calculated. Statistical analyses were conducted with the SAP System V9.2.
Between 2013 and 2014, the HIV Symptoms Index Questionnaire was applied to 75 patients; 95% of these patients considered the questionnaire was easy to apply and understand. The total median score of the questionnaire was nine symptoms (IQR 1-18); and the most frequent symptoms were nerves or anxiety (45%), stomach swelling, pain or gas (40%), sleep problems (39%), and fatigue or lack of energy (37%). Presence of symptoms was associated with a worse outcome in the MOS-HIV questionnaire. According to the Visual Analogue Scale, the higher the score in the questionnaire, the lower the tolerance level (R = -0.51; p < 0.0001), and the higher number of days with symptoms (R = 0.51; p < 0.0001).
The questionnaire was easy to apply. A high tolerance level was confirmed, as well as a consistent and significant correlation with the MOS-HIV and the Visual Analogue Scale.
主要终点是在西班牙人群中验证艾滋病病毒症状指数问卷在理解性和可接受性方面的情况。次要终点是描述患者报告的症状、耐受性和生活质量。
这是一项观察性、多中心、非对照研究的试点试验，旨在验证西班牙人群中的艾滋病病毒症状指数问卷。纳入年龄在18岁以上、诊断为艾滋病病毒感染并接受治疗的患者。计算症状指数、基于药房配药记录的治疗依从性以及使用MOS-HIV问卷评估的生活质量。使用SAP系统V9.2进行统计分析。
在2013年至2014年期间，艾滋病病毒症状指数问卷应用于75名患者；其中95%的患者认为该问卷易于应用和理解。问卷的总中位数得分是9种症状（四分位间距为1-18）；最常见的症状是神经紧张或焦虑（45%）、胃部肿胀、疼痛或胀气（40%）、睡眠问题（39%）以及疲劳或精力不足（37%）。症状的出现与MOS-HIV问卷中较差的结果相关。根据视觉模拟量表，问卷得分越高，耐受性水平越低（R = -0.51；p < 0.0001），有症状的天数越多（R = 0.51；p < 0.0001）。
该问卷易于应用。证实了较高的耐受性水平，以及与MOS-HIV和视觉模拟量表之间存在一致且显著的相关性。
