实验性自身免疫性脑脊髓炎小鼠脊髓神经元中巨噬细胞集落刺激因子 CSF-1 的表达。
Expression of Macrophage Colony-Stimulating Factor CSF-1 in Spinal Cord Neurons in Mice with Experimental Autoimmune Encephalomyelitis.
机构信息
Department of Cytology, Histology, and Embryology with Courses in Medical Biology and Molecular Biology of the Cell, N. P. Ogarev National Research Mordovia State University, Saransk, Republic of Mordovia, Russia.
Department of Normal and Pathological Anatomy with a Course of Forensic Medicine, N. P. Ogarev National Research Mordovia State University, Saransk, Republic of Mordovia, Russia.
出版信息
Bull Exp Biol Med. 2024 Sep;177(5):682-685. doi: 10.1007/s10517-024-06249-y. Epub 2024 Oct 1.
In mice with acute and chronic models of experimental autoimmune encephalomyelitis (EAE), a quantitative study of the dynamics of CSF-1 and IL-34 protein levels in the spinal cord and blood plasma was conducted by ELISA and the specificity of CSF-1 expression in spinal cord cells was examined by immunohistological methods. A significant increase in the level of CSF-1 in the spinal cord was detected and populations of motoneurons with intense CSF-1 immunoreactivity were identified in mice with acute and chronic EAE. The obtained results suggest a possible role of CSF-1 in the pathogenesis and progression of EAE/multiple sclerosis.
在实验性自身免疫性脑脊髓炎（EAE）的急性和慢性模型的小鼠中，通过 ELISA 进行了 CSF-1 和 IL-34 蛋白水平在脊髓和血浆中的动态的定量研究，并通过免疫组织化学方法检查了 CSF-1 在脊髓细胞中的表达特异性。在急性和慢性 EAE 的小鼠中，检测到脊髓中 CSF-1 水平显著增加，并鉴定出具有强烈 CSF-1 免疫反应性的运动神经元群体。所得结果表明 CSF-1 在 EAE/多发性硬化症的发病机制和进展中可能发挥作用。
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