Department of Neurosurgery of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, China.
Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China.
Elife. 2024 Oct 1;13:RP97545. doi: 10.7554/eLife.97545.
The prevailing opinion emphasizes fronto-parietal network (FPN) is key in mediating general fluid intelligence (gF). Meanwhile, recent studies show that human MT complex (hMT+), located at the occipito-temporal border and involved in 3D perception processing, also plays a key role in gF. However, the underlying mechanism is not clear, yet. To investigate this issue, our study targets visuo-spatial intelligence, which is considered to have high loading on gF. We use ultra-high field magnetic resonance spectroscopy (MRS) to measure GABA/Glu concentrations in hMT+ combining resting-state fMRI functional connectivity (FC), behavioral examinations including hMT+ perception suppression test and gF subtest in visuo-spatial component. Our findings show that both GABA in hMT+ and frontal-hMT+ functional connectivity significantly correlate with the performance of visuo-spatial intelligence. Further, serial mediation model demonstrates that the effect of hMT+ GABA on visuo-spatial gF is fully mediated by the hMT+ frontal FC. Together our findings highlight the importance in integrating sensory and frontal cortices in mediating the visuo-spatial component of general fluid intelligence.
主流观点强调额顶网络（FPN）是介导一般流体智力（gF）的关键。而最近的研究表明，位于枕颞边界并参与 3D 感知处理的人类 MT 复合体（hMT+）在 gF 中也起着关键作用。然而，其潜在机制尚不清楚。为了研究这个问题，我们的研究针对视觉空间智力，它被认为对 gF 有很高的负荷。我们使用超高场磁共振波谱（MRS）测量 hMT+中的 GABA/Glu 浓度，结合静息态 fMRI 功能连接（FC），包括 hMT+感知抑制测试和 gF 子测试的行为测试，进行视觉空间成分。我们的发现表明，hMT+中的 GABA 和额 hMT+功能连接均与视觉空间智力的表现显著相关。此外，序列中介模型表明，hMT+GABA 对视觉空间 gF 的影响完全由 hMT+额 FC 介导。综上所述，我们的研究结果强调了在介导一般流体智力的视觉空间成分中整合感觉和额皮质的重要性。
