College of Arts & Sciences, Boston University, MA.
Program for Patient Safety and Quality, Boston Children's Hospital, MA.
Am J Speech Lang Pathol. 2024 Nov 4;33(6):3069-3081. doi: 10.1044/2024_AJSLP-23-00421. Epub 2024 Oct 1.
This study investigated treatment-induced performance gains in memory function following therapy through the Intensive Cognitive Communication Rehabilitation (ICCR) program for young adults with acquired brain injury (ABI). We aimed to determine the utility of a novel approach to measuring memory performance improvement across semesters of therapy using (a) systematic treatment tasks called Individualized Quantitative Protocols (IQPs) as compared to (b) standardized measures of memory function.
Retrospective IQP data spanning five consecutive ICCR semesters were collected from patients ( = 13) with ABI. Raw task-accuracy data were scaled to account for task difficulty gradation. Linear mixed-effects models (LMMs) were used to evaluate the degree of memory improvement-measured by scaled IQP scores-as a function of therapy duration, age, time postinjury, and aphasia; pre- to posttreatment effect sizes were also calculated. For comparison, similar LMMs were run using standardized metrics of memory abilities as the outcome measure.
Results showed significant treatment-induced improvements, with gains at the session level (β = 2.76; = 2.23; = .047), when improvement was measured using IQP scaled scores. Standardized metrics did not show significant improvement as a function of therapy. Effect size analysis mirrored LMM results, with a large ( = 0.92, 95% confidence interval [0.35, 1.49]) pre- to posttreatment effect when change was measured using IQP scaled scores and a small effect for standardized measures.
This preliminary study demonstrates the utility of a granular, individualized metric to index significant impairment-based performance gains following ICCR treatment. These results introduce promise for future analysis of complex treatment data. Additionally, they provide another lens with which to assess treatment progress and its significance.
本研究通过针对后天性脑损伤(ABI)年轻成人的密集认知沟通康复(ICCR)计划,调查治疗后记忆功能的治疗诱导性表现提升。我们旨在确定一种新方法的实用性,该方法通过使用(a)称为个体化量化方案(IQP)的系统治疗任务与(b)记忆功能的标准化测量,来衡量整个治疗学期的记忆表现改善。
从患有 ABI 的患者(n=13)中收集了跨越五个连续 ICCR 学期的回顾性 IQP 数据。原始任务准确性数据被缩放以说明任务难度分级。线性混合效应模型(LMM)用于评估记忆改善程度-以标准化 IQP 分数衡量-作为治疗持续时间、年龄、受伤后时间和失语症的函数;还计算了治疗前至治疗后的效应量。为了比较,使用记忆能力的标准化度量作为因变量,运行了类似的 LMM。
结果显示出显著的治疗诱导性改善,当使用 IQP 标准化分数衡量时,会话水平上有提高(β=2.76;标准误[SE]=2.23;P=.047)。作为治疗函数,标准化指标没有显示出显著改善。效应量分析与 LMM 结果相吻合,当使用 IQP 标准化分数衡量变化时,治疗前至治疗后的效应量较大(d=0.92,95%置信区间[0.35, 1.49]),而标准化指标的效应量较小。
这项初步研究证明了一种粒度精细、个体化的指标在 ICCR 治疗后评估显著基于损伤的表现提升的实用性。这些结果为未来分析复杂的治疗数据提供了希望。此外,它们提供了另一个评估治疗进展及其意义的视角。