Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China.
Biomed Pharmacother. 2024 Nov;180:117498. doi: 10.1016/j.biopha.2024.117498. Epub 2024 Sep 30.
Staphylococcus aureus (S. aureus) infection is the most prevalent and resistant bacterial infection, posing a worldwide health risk. Compared with healthy people, diabetes patients with weak immune function and abnormal metabolism are more vulnerable to bacterial infection, which aggravates the intensity of infection and causes a series of common and dangerous complications, such as diabetes foot ulcer (DFU). Due to metabolic abnormalities of diabetic patients, S. aureus on the skin surface of DFU transitions from a commensal to an invasive infection. During this process, S. aureus resists a series of unfavorable conditions for bacterial growth by altering energy utilization and metabolic patterns, and secretes various virulence factors, causing persistent infection. With the emergence of multiple super-resistant bacteria, antibiotic treatment is no longer the only treatment option, and developing new drugs and therapies is urgent. Regulating the metabolic signaling pathway of S. aureus plays a decisive role in regulating its virulence factors and impacts adjuvant therapy for DFU. This article focuses on studying the impact of regulating metabolic signals on the virulence of S. aureus from a metabolism perspective. It provides an outlook on the future direction of the novel development of antimicrobial therapy.
金黄色葡萄球菌（S. aureus）感染是最普遍和最具耐药性的细菌感染，对全球健康构成威胁。与健康人相比，免疫功能较弱和代谢异常的糖尿病患者更容易受到细菌感染，这会加重感染的强度，并导致一系列常见且危险的并发症，如糖尿病足溃疡（DFU）。由于糖尿病患者的代谢异常，DFU 皮肤表面的金黄色葡萄球菌从共生菌转变为侵袭性感染。在此过程中，金黄色葡萄球菌通过改变能量利用和代谢模式来抵抗一系列不利于细菌生长的条件，并分泌各种毒力因子，导致持续感染。随着多种超级耐药菌的出现，抗生素治疗不再是唯一的治疗选择，因此迫切需要开发新的药物和治疗方法。调节金黄色葡萄球菌的代谢信号通路在调节其毒力因子方面起着决定性作用，这对 DFU 的辅助治疗有重要影响。本文从代谢角度出发，重点研究调节代谢信号对金黄色葡萄球菌毒力的影响，为新型抗菌治疗药物的开发提供了未来的研究方向。
