Department of Obstetrics and Gynecology, Quanzhou Medical College, Quanzhou, Fujian 362010, China.
Department of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China; Key Clinical Specialty of Liaoning Province, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang 110042, China; Central Laboratory, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China; Department of Gynecology, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.
Biomed Pharmacother. 2024 Nov;180:117483. doi: 10.1016/j.biopha.2024.117483. Epub 2024 Sep 30.
The progression of high-grade squamous intraepithelial lesion (HSIL) to invasive cervical cancer (ICC) is a complex process involving persistent human papillomavirus (HPV) infection and changes in signal transduction regulation, energy and material metabolism, cell proliferation, autoimmune, and other biological process in vaginal microenvironment and immune microenviroment. Signaling pathways are a series of interacting molecules in cells that regulate various physiological functions of cells, such as growth, differentiation, metabolism, and death. In the progression of HSIL to ICC, abnormal activation or inhibition in signaling pathways plays an essensial role. This review presented some signaling pathways related to the malignant progression of HSIL to ICC, including p53, Rb, PI3K/AKT/mTOR, Wnt/β-catenin, Notch, NF-κB, MAPK, TGF-β, JAK-STAT, Hippo, and Hedgehog. The molecular mechanisms involved in the biological process of pathway regulation were also analyzed, in order to illustrate the molecular pathway of HSIL progression to ICC and provide references for the development of more effective prevention and treatment methods.
高级别鳞状上皮内病变（HSIL）进展为宫颈癌（ICC）是一个涉及持续性人乳头瘤病毒（HPV）感染以及阴道微环境和免疫微环境中信号转导调节、能量和物质代谢、细胞增殖、自身免疫等生物学过程变化的复杂过程。信号通路是细胞内一系列相互作用的分子，调节细胞的各种生理功能，如生长、分化、代谢和死亡。在 HSIL 进展为 ICC 的过程中，信号通路的异常激活或抑制起着重要作用。本综述介绍了一些与 HSIL 进展为 ICC 的恶性转化相关的信号通路，包括 p53、Rb、PI3K/AKT/mTOR、Wnt/β-catenin、Notch、NF-κB、MAPK、TGF-β、JAK-STAT、Hippo 和 Hedgehog。还分析了通路调节的生物学过程中涉及的分子机制，以便阐明 HSIL 进展为 ICC 的分子通路，并为开发更有效的预防和治疗方法提供参考。
