锝-99m-N，N-双（巯基乙酰基）-2，3-二氨基丙酸酯与锝-99m二乙三胺五乙酸用于肾脏显像的临床比较。

Clinical comparison of technetium-99m-N,N-bis(mercaptoacetyl)-2,3-diaminopropanoate with technetium-99m DTPA for renal imaging.

作者信息

Kuni C C, Klingensmith W C, Fritzberg A R, Spitzer V M, Latteier J L

出版信息

Clin Nucl Med. 1985 Nov;10(11):810-3. doi: 10.1097/00003072-198511000-00015.

DOI:10.1097/00003072-198511000-00015

Abstract

We studied 14 patients having serum creatinines of 1.0 to 12.8 mg/dl with either Tc-99m-N,N'-bis(mercaptoacetyl)-2,3-diaminopropanoate (CO2-DADS) or Tc-99m DTPA, and within 48 hours with the other agent. Analog and digital images of the kidneys and bladder were acquired for 30 minutes after injection and after voiding. The kidney-to-background ratio at 3 minutes for Tc-99m CO2-DADS was 2.01 +/- 0.79 (mean +/- SD) times that for Tc-99m DTPA (P less than 0.001). The parenchymal transit time for Tc-99m CO2-DADS was 1.34 +/- 0.25 (mean +/- SD) times that for Tc-99m DTPA (P less than 0.005). The percent-excreted dose at 30 minutes for Tc-99m CO2-DADS was 2.57 +/- 1.24 (mean +/- SD) times that for Tc-99m DTPA (P less than 0.001). Analog Tc-99m CO2-DADS images showed spatial resolution comparable to that for Tc-99m DTPA. Hepatobiliary excretion was never seen. Tc-99m CO2-DADS appears to be generally superior to Tc-99m DTPA as a renal radiopharmaceutical.

摘要

我们研究了14例血清肌酐水平在1.0至12.8mg/dl之间的患者，先给予他们锝-99m-N,N'-双（巯基乙酰基）-2,3-二氨基丙酸（CO2-DADS）或锝-99m二乙三胺五乙酸（DTPA），48小时内再给予另一种药物。注射后及排尿后采集肾脏和膀胱的模拟图像及数字图像，持续30分钟。锝-99m CO2-DADS在3分钟时的肾本底比是锝-99m DTPA的2.01±0.79（平均值±标准差）倍（P<0.001）。锝-99m CO2-DADS的实质通过时间是锝-99m DTPA的1.34±0.25（平均值±标准差）倍（P<0.005）。锝-99m CO2-DADS在30分钟时的排泄剂量百分比是锝-99m DTPA的2.57±1.24（平均值±标准差）倍（P<0.001）。模拟的锝-99m CO2-DADS图像显示其空间分辨率与锝-99m DTPA相当。未观察到肝胆排泄情况。作为一种肾放射性药物，锝-99m CO2-DADS总体上似乎优于锝-99m DTPA。