Wang Qianqian, Wang Zhaoxiang, Sun Yuyan, Tang Fengyan, Lu Bing, Zhou Kaixin, Pan Ying, Zhong Shao
Department of Endocrinology, Affiliated Kunshan Hospital of Jiangsu University, Jiangsu, 215300, China.
Gusu School, Nanjing Medical University, The First People's Hospital of Kunshan, Kunshan, Jiangsu, 215300, China.
Nutr Metab Cardiovasc Dis. 2024 Dec;34(12):2749-2756. doi: 10.1016/j.numecd.2024.08.018. Epub 2024 Aug 30.
Elevated serum uric acid (SUA) levels are an important marker of metabolic disorders. However, SUA levels largely depend on renal clearance function. This study aims to investigate the relationship between renal function-normalized SUA [SUA to serum creatinine (SCr) ratio] and the risk of developing type 2 diabetes in a community-dwelling elderly population.
A retrospective cohort study was conducted on elderly, non-diabetic individuals from the Kunshan community in China, who participated in annual health check-ups between January 2018 and December 2023. The relationship between the baseline SUA/SCr ratio and the risk of type 2 diabetes was examined using Cox regression models, restricted cubic splines (RCS), and subgroup analyses. After a median follow-up of 3.88 years, 778 cases of type 2 diabetes were identified among 7671 elderly non-diabetic individuals. Adjusting for confounding variables, the baseline SUA/SCr ratio was significantly linked to type 2 diabetes risk (P < 0.001). Individuals in the highest SUA/SCr ratio quartile had a 1.323 times higher risk of developing type 2 diabetes compared to those in the lowest quartile (HR = 1.323, 95% CI 1.053-1.661, P = 0.016). RCS analysis further confirmed this positive association. Additionally, subgroup analyses suggested that this relationship was particularly pronounced in female individuals.
In Chinese elderly community residents, the baseline SUA/SCr ratio is linked to the risk of type 2 diabetes. Monitoring this ratio could aid in predicting and assessing the risk of type 2 diabetes.
血清尿酸（SUA）水平升高是代谢紊乱的重要标志物。然而，SUA水平很大程度上取决于肾脏清除功能。本研究旨在探讨肾功能标准化的SUA[SUA与血清肌酐（SCr）比值]与社区居住老年人群发生2型糖尿病风险之间的关系。
对2018年1月至2023年12月期间参加年度健康检查的中国昆山社区老年非糖尿病个体进行了一项回顾性队列研究。使用Cox回归模型、限制性立方样条（RCS）和亚组分析来检验基线SUA/SCr比值与2型糖尿病风险之间的关系。在中位随访3.88年后，在7671名老年非糖尿病个体中确定了778例2型糖尿病病例。调整混杂变量后，基线SUA/SCr比值与2型糖尿病风险显著相关（P<0.001）。SUA/SCr比值最高四分位数的个体发生2型糖尿病的风险是最低四分位数个体的1.323倍（HR=1.323，95%CI 1.053-1.661，P=0.016）。RCS分析进一步证实了这种正相关关系。此外，亚组分析表明这种关系在女性个体中尤为明显。
在中国老年社区居民中，基线SUA/SCr比值与2型糖尿病风险相关。监测该比值有助于预测和评估2型糖尿病风险。
