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丙型肝炎病毒感染与帕金森病：来自联合性别分层 BioOptimatics 荟萃分析的新见解。

Hepatitis C virus infection and Parkinson's disease: insights from a joint sex-stratified BioOptimatics meta-analysis.

机构信息

Bioengineering Graduate Program, The Applied Optimization Group, University of Puerto Rico-Mayagüez, Mayagüez, 00681, Puerto Rico.

Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, 33612, USA.

出版信息

Sci Rep. 2024 Oct 1;14(1):22838. doi: 10.1038/s41598-024-73535-0.

DOI:10.1038/s41598-024-73535-0
PMID:39354018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11445468/
Abstract

Hepatitis C virus (HCV) infection poses a significant public health challenge and often leads to long-term health complications and even death. Parkinson's disease (PD) is a progressive neurodegenerative disorder with a proposed viral etiology. HCV infection and PD have been previously suggested to be related. This work aimed to identify potential biomarkers and pathways that may play a role in the joint development of PD and HCV infection. Using BioOptimatics-bioinformatics driven by mathematical global optimization-, 22 publicly available microarray and RNAseq datasets for both diseases were analyzed, focusing on sex-specific differences. Our results revealed that 19 genes, including MT1H, MYOM2, and RPL18, exhibited significant changes in expression in both diseases. Pathway and network analyses stratified by sex indicated that these gene expression changes were enriched in processes related to immune response regulation in females and immune cell activation in males. These findings suggest a potential link between HCV infection and PD, highlighting the importance of further investigation into the underlying mechanisms and potential therapeutic targets involved.

摘要

丙型肝炎病毒 (HCV) 感染对公共健康构成重大挑战，常导致长期健康并发症，甚至死亡。帕金森病 (PD) 是一种进行性神经退行性疾病，其病因被认为与病毒有关。先前有研究表明丙型肝炎病毒感染与帕金森病有关。本研究旨在鉴定可能在帕金森病和丙型肝炎病毒感染共同发展中起作用的潜在生物标志物和途径。使用由数学全局优化驱动的 BioOptimatics 生物信息学方法，分析了这两种疾病的 22 个公开微阵列和 RNAseq 数据集，重点关注性别特异性差异。我们的结果表明，包括 MT1H、MYOM2 和 RPL18 在内的 19 个基因在两种疾病中的表达均发生显著变化。按性别分层的通路和网络分析表明，这些基因表达变化在女性的免疫反应调节和男性的免疫细胞激活相关过程中富集。这些发现提示丙型肝炎病毒感染与帕金森病之间可能存在关联，强调了进一步研究潜在机制和潜在治疗靶点的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/c9a468b2a20b/41598_2024_73535_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/5a89faea7f11/41598_2024_73535_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/7d8bcb21528a/41598_2024_73535_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/4fa1096473f0/41598_2024_73535_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/fda62c5a83e6/41598_2024_73535_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/e1d773ad4e9e/41598_2024_73535_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/c9a468b2a20b/41598_2024_73535_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/5a89faea7f11/41598_2024_73535_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/9d9c2ad3e037/41598_2024_73535_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/d800e27a2037/41598_2024_73535_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/8d9f38e9b0d7/41598_2024_73535_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/7d8bcb21528a/41598_2024_73535_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/4fa1096473f0/41598_2024_73535_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/fda62c5a83e6/41598_2024_73535_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/e1d773ad4e9e/41598_2024_73535_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af62/11445468/c9a468b2a20b/41598_2024_73535_Fig9_HTML.jpg

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